Evidence map›Paper›PMID 30001182›Full record

ReviewAnnual review of virology2018

Phage-Based Applications in Synthetic Biology.

Sebastien Lemire, Kevin M Yehl, Timothy K Lu

Abstract readReview
In one paragraph

Review in Annual review of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
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  6. Article
  7. Review
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  9. Article
  10. Article
  11. Review
  12. Hashing the message with cells.Nature chemical biology · 2025
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sebastien LemireResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; email: timlu@mit.edu.
Kevin M YehlResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; email: timlu@mit.edu.
Timothy K LuResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; email: timlu@mit.edu.

Funding

MIT Center for Integrative Synthetic BiologyP50GM098792 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WEISS, RON · 2013 to 2017
$11.0M
Engineering “Phagebody” Antimicrobials for Carbapenem-Resistant EnterobacteriaceaeR33AI121669 · NIAID · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LU, TIMOTHY · 2018 to 2020
$1.3M
Engineering “Phagebody” Antimicrobials for Carbapenem-Resistant EnterobacteriaceaeR21AI121669 · NIAID · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LU, TIMOTHY · 2016 to 2017
$403k
NIAID NIH HHS R21 AI121669NIAID NIH HHS R33 AI121669NIGMS NIH HHS P50 GM098792
6 · The paper itself

Abstract

Bacteriophage research has been instrumental to advancing many fields of biology, such as genetics, molecular biology, and synthetic biology. Many phage-derived technologies have been adapted for building gene circuits to program biological systems. Phages also exhibit significant medical potential as antibacterial agents and bacterial diagnostics due to their extreme specificity for their host, and our growing ability to engineer them further enhances this potential. Phages have also been used as scaffolds for genetically programmable biomaterials that have highly tunable properties. Furthermore, phages are central to powerful directed evolution platforms, which are being leveraged to enhance existing biological functions and even produce new ones. In this review, we discuss recent examples of how phage research is influencing these next-generation biotechnologies.

Indexed as

Bacterial InfectionsBacteriophagesBiotechnologyDiagnostic Tests, RoutineHumansMolecular BiologyPhage TherapySynthetic Biologydiagnosticsgene circuitgene synthesisintegraselysinphagephage-based materialsphage displayphage therapyrecombinaseRNA polymerasesynthetic biologytranscriptional regulator

Identifiers

PMID30001182
PMCPMC6953747

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.