Evidence map›Paper›PMID 29999466›Full record

ArticleTissue engineering. Part A2018

Lattice Microarchitecture for Bone Tissue Engineering from Calcium Phosphate Compared to Titanium.

Tse-Hsiang Chen, Chafik Ghayor, Barbara Siegenthaler, Felix Schuler, Jasmine Rüegg, Michael De Wild, Franz E Weber

Open access · hybridAbstract read
In one paragraph

Article in Tissue engineering. Part A, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Tse-Hsiang Chen1 Oral Biotechnology and Bioengineering, Center of Dental Medicine, University of Zurich , Zurich, Switzerland .
Chafik Ghayor1 Oral Biotechnology and Bioengineering, Center of Dental Medicine, University of Zurich , Zurich, Switzerland .
Barbara Siegenthaler1 Oral Biotechnology and Bioengineering, Center of Dental Medicine, University of Zurich , Zurich, Switzerland .
Felix Schuler2 School of Life Sciences, Institute for Medical and Analytical Technologies, University of Applied Sciences Northwestern Switzerland , Muttenz, Switzerland .
Jasmine Rüegg2 School of Life Sciences, Institute for Medical and Analytical Technologies, University of Applied Sciences Northwestern Switzerland , Muttenz, Switzerland .
Michael De Wild2 School of Life Sciences, Institute for Medical and Analytical Technologies, University of Applied Sciences Northwestern Switzerland , Muttenz, Switzerland .
Franz E Weber1 Oral Biotechnology and Bioengineering, Center of Dental Medicine, University of Zurich , Zurich, Switzerland .
FHNW University of Applied Sciences and Arts · CHBioengineering (Switzerland) · CHSwiss Integrative Center for Human Health · CHUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Additive manufacturing of bone tissue engineering scaffolds will become a key element for personalized bone tissue engineering in the near future. Several additive manufacturing processes are based on extrusion where the deposition of the filament will result in a three-dimensional lattice structure. Recently, we studied diverse lattice structures for bone tissue engineering realized by laser sintering of titanium. In this work, we used lithography-based ceramic manufacturing of lattice structures to produce scaffolds from tricalcium phosphates (TCP) and compared them in vivo to congruent titanium scaffolds manufactured with the identical computer-aided design data to look for material-based differences in bony healing. The results show that, during a 4-week period in a noncritical-size defect in a rabbit calvarium, both scaffolds with the identical microarchitecture performed equally well in terms of bony regeneration and bony bridging of the defect. A significant increase in both parameters could only be achieved when the TCP-based scaffolds were doped with bone morphogenetic protein-2. In a critical-size defect in the calvarial bone of rabbits, however, the titanium scaffold performed significantly better than the TCP-based scaffold, most likely due to its higher mechanical stability. We conclude that titanium and TCP-based scaffolds of the same microarchitecture perform equally well in terms of bone regeneration, provided the microarchitecture meets the mechanical demand at the site of implantation.

Indexed as

AnimalsBone and BonesCalcium PhosphatesRabbitsSkullTissue EngineeringTissue ScaffoldsTitaniumCalcium PhosphatesTitaniumtricalcium phosphateadditive manufacturingbone regenerationbone repaircalcium phosphatelattice architecturelithographyosteoconductiontitanium

Identifiers

PMID29999466
PMCPMC6198759
OpenAlexW2889592653

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.