ReviewJournal of neurosurgery2019
Rates and predictors of seizure outcome after corpus callosotomy for drug-resistant epilepsy: a meta-analysis.
Review in Journal of neurosurgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Outcomes following resective and disconnective strategies in the treatment of epileptic spasms: a systematic review of the literature and individual patient data meta-analysis.Frontiers in neurology · 2024Pooled it
- Long-term follow-up seizure outcomes after corpus callosotomy: A systematic review with meta-analysis.Brain and behavior · 2023Pooled it
- Effect of time to palliative epilepsy surgery on outcomes.Epilepsia · 2026Article
- Comparative effects of posterior versus total corpus callosotomy in a PTZ-induced rat model of epilepsy: a methodological pilot study.Experimental brain research · 2026Article
- Article
- Beyond seizures: understanding adaptive functioning in drug-resistant epilepsy in patients undergoing palliative surgery.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Observational
- Review
- Endoscopic corpus callosotomy for drug-resistant epilepsy due to cerebral folate transporter deficiency: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Epileptogenesis and Epilepsy Treatment: Advances in Mechanistic Understanding, Therapeutic Approaches, and Future Perspectives.International journal of molecular sciences · 2026Review
- People with epilepsy and intellectual disability.Acta neurologica Belgica · 2025Review
- Epileptic drop attacks: More than just atonic seizures.Epilepsia open · 2025Article
- Long-term outcomes of corpus callosotomy in adult patients with drug-resistant epilepsy: Results from a single neurosurgical center in Mexico.Epilepsia open · 2025Article
- A Standardized Approach to MRI-Guided Stereotactic Laser Corpus Callosotomy: Technical Description and Pediatric Case Series.Operative neurosurgery (Hagerstown, Md.) · 2025Article
- Corpus callosotomy for intractable epilepsy in the pediatric population: value of intraoperative neurophysiological monitoring.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Review
- Review
- Changes in interhemispheric coherence after total corpus callosotomy: a scalp EEG study in children with non-lesional generalized epilepsy.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Applications of magnetic resonance-guided laser interstitial thermal therapy in disconnective epilepsy surgery.Frontiers in neurology · 2024Review
- Influence of extent and age at corpus callosotomy on seizure outcomes. A single center experience.Epilepsia open · 2023Article
- Association Between Characteristics of National Association of Epilepsy Centers and Reported Utilization of Specific Surgical Techniques.Neurology · 2023Article
- Magnetic resonance imaging-guided laser interstitial thermal therapy for complete corpus callosotomy: technique and 1-year outcomes. Patient series.Journal of neurosurgery. Case lessons · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveCorpus callosotomy is a palliative surgery for drug-resistant epilepsy that reduces the severity and frequency of generalized seizures by disconnecting the two cerebral hemispheres. Unlike with resection, seizure outcomes remain poorly understood. The authors systematically reviewed the literature and performed a meta-analysis to investigate rates and predictors of complete seizure freedom and freedom from drop attacks after corpus callosotomy.
methodsPubMed, Web of Science, and Scopus were queried for primary studies examining seizure outcomes after corpus callosotomy published over 30 years. Rates of complete seizure freedom or drop attack freedom were recorded. Variables showing a potential relationship to seizure outcome on preliminary analysis were subjected to formal meta-analysis.
resultsThe authors identified 1742 eligible patients from 58 included studies. Overall, the rates of complete seizure freedom and drop attack freedom after corpus callosotomy were 18.8% and 55.3%, respectively. Complete seizure freedom was significantly predicted by the presence of infantile spasms (OR 3.86, 95% CI 1.13-13.23), normal MRI findings (OR 4.63, 95% CI 1.75-12.25), and shorter epilepsy duration (OR 2.57, 95% CI 1.23-5.38). Freedom from drop attacks was predicted by complete over partial callosotomy (OR 2.90, 95% CI 1.07-7.83) and idiopathic over known epilepsy etiology (OR 2.84, 95% CI 1.35-5.99).
conclusionsThe authors report the first systematic review and meta-analysis of seizure outcomes in both adults and children after corpus callosotomy for epilepsy. Approximately one-half of patients become free from drop attacks, and one-fifth achieve complete seizure freedom after surgery. Some predictors of favorable outcome differ from those in resective epilepsy surgery.
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Registered trials
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