Evidence map›Paper›PMID 29999305›Full record

ArticleBiochemistry2018

Nitrosyl Myoglobins and Their Nitrite Precursors: Crystal Structural and Quantum Mechanics and Molecular Mechanics Theoretical Investigations of Preferred Fe -NO Ligand Orientations in Myoglobin Distal Pockets.

Bing Wang, Yelu Shi, Jesús Tejero, Samantha M Powell, Leonard M Thomas, Mark T Gladwin, Sruti Shiva, Yong Zhang, George B Richter-Addo

Abstract read
In one paragraph

Article in Biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Unveiling an Ultrareduced State of Heme in Myoglobin.Journal of the American Chemical Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Bing WangPrice Family Foundation Institute of Structural Biology and Department of Chemistry and Biochemistry , University of Oklahoma , 101 Stephenson Parkway , Norman , Oklahoma 73019 , United States.
Yelu ShiDepartment of Chemistry and Chemical Biology , Stevens Institute of Technology , Castle Point on Hudson , Hoboken , New Jersey 07030 , United States.
Jesús TejeroHeart, Lung, Blood and Vascular Medicine Institute , University of Pittsburgh School of Medicine , 3550 Terrace Street , Pittsburgh , Pennsylvania 15261 , United States.ORCID 0000-0003-3245-9978
Samantha M PowellPrice Family Foundation Institute of Structural Biology and Department of Chemistry and Biochemistry , University of Oklahoma , 101 Stephenson Parkway , Norman , Oklahoma 73019 , United States.
Leonard M ThomasPrice Family Foundation Institute of Structural Biology and Department of Chemistry and Biochemistry , University of Oklahoma , 101 Stephenson Parkway , Norman , Oklahoma 73019 , United States.
Mark T GladwinHeart, Lung, Blood and Vascular Medicine Institute , University of Pittsburgh School of Medicine , 3550 Terrace Street , Pittsburgh , Pennsylvania 15261 , United States.
Sruti ShivaDepartment of Pharmacology and Chemical Biology , University of Pittsburgh , 200 Lothrop Street , Pittsburgh , Pennsylvania 15213 , United States.
Yong ZhangDepartment of Chemistry and Chemical Biology , Stevens Institute of Technology , Castle Point on Hudson , Hoboken , New Jersey 07030 , United States.ORCID 0000-0001-7207-6416
George B Richter-AddoPrice Family Foundation Institute of Structural Biology and Department of Chemistry and Biochemistry , University of Oklahoma , 101 Stephenson Parkway , Norman , Oklahoma 73019 , United States.ORCID 0000-0001-9400-0113
University of Oklahoma · USUniversity of Pittsburgh · USStevens Institute of Technology · US

Funding

Vascular Subphenotypes of Lung DiseaseP01HL103455 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GLADWIN, MARK T · 2011 to 2020
$26.1M
Structure-Function Studies of MsvR, a Methanogen-Specific Transcriptional RegulaP20GM103640 · NIGMS · UNIVERSITY OF OKLAHOMA · PI THOMAS, LEONARD M · 2012 to 2021
$20.4M
Storage Lesion in Banked Blood Due to Disruption of Nitric Oxide HomeostasisR01HL098032 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Mark T Gladwin · 2009 to 2026
$12.5M
Antidote for inhaled CO poisoning based on mutationally engineered neuroglobinR01HL125886 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Mark T Gladwin, Jesus Tejero Bravo · 2015 to 2026
$7.9M
Translational Pulmonary Vascular BiologyT32HL110849 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sruti Shiva · 2012 to 2026
$5.0M
Myoglobin as a Nitrite Reductase that Regulates Hypoxic Cardiac NO SignalingR01HL096973 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GLADWIN, MARK T, SHIVA, SRUTI · 2010 to 2013
$1.5M
Structure, Spectra, and Roles of Metal and Active Site in HNO Heme Protein CompleR15GM085774 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI ZHANG, YONG · 2008 to 2021
$1.4M
NHLBI NIH HHS P01 HL103455NHLBI NIH HHS R01 HL096973NHLBI NIH HHS R01 HL098032NHLBI NIH HHS R01 HL125886NHLBI NIH HHS T32 HL110849NIGMS NIH HHS P20 GM103640NIGMS NIH HHS R15 GM085774
6 · The paper itself

Abstract

The globular dioxygen binding heme protein myoglobin (Mb) is present in several species. Its interactions with the simple nitrogen oxides, namely, nitric oxide (NO) and nitrite, have been known for decades, but the physiological relevance has only recently become more fully appreciated. We previously reported the O-nitrito mode of binding of nitrite to ferric horse heart wild-type (wt) Mb

Indexed as

AnimalsCrystallography, X-RayHorsesHumansMutationMyoglobinNitric OxideNitritesNitrogen OxidesProtein ConformationMyoglobinNitric OxideNitritesNitrogen Oxides

Identifiers

PMID29999305
PMCPMC6474360
OpenAlexW2879527482

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.