ArticleChinese medical journal2018
Glomerular Filtration Rate is Associated with Hemorrhagic Transformation in Acute Ischemic Stroke Patients without Thrombolytic Therapy.
Article in Chinese medical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Predictive Value of the Modified Comprehensive Immunoinflammatory Indices for Hemorrhagic Transformation in Ischemic Stroke Patients Undergoing Thrombolysis: A Retrospective Study.International journal of general medicine · 2025Article
- Effect of Continuous Nursing Model Based on WeChat Public Health Education on Self-Management Level and Treatment Compliance of Stroke Patients.Iranian journal of public health · 2022Article
- Antithrombotic Management and Long-Term Outcomes of Patients with Atrial Fibrillation. Insights from CRAFT Trial.Journal of clinical medicine · 2021Article
- Hemostasis functions are associated with hemorrhagic transformation in non-atrial fibrillation patients: a case-control study.BMC neurology · 2021Article
- Current Trends Featuring the Bridge Between Stroke and End-Stage Renal Disease: A Review.Cureus · 2020Review
- Incidence and Risk Factors of Postcontrast Acute Kidney Injury in Patients with Acute Ischemic Stroke.Stroke research and treatment · 2020Article
- Renal Fibrosis and Mitochondrial Damage.Chinese medical journal · 2018Article
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Abstract
backgroundWhether there is a relationship between glomerular filtration rate (GFR) and hemorrhagic transformation (HT) after acute ischemic stroke (AIS) is still under debate. The aim of our study was to determine whether the GFR level is a predictor of HT in AIS patients without thrombolytic therapy (TT).
methodsConsecutive AIS patients without TT were included in this prospective study from January 2014 to December 2016 in the First Affiliated Hospital of Chongqing Medical University. We divided them into two groups (HT and non-HT group) and meticulously collected baseline characteristics and laboratory and imaging data of interested individuals. Multivariate regression analysis was performed to assess the correlation between GFR and HT in stroke patients without TT.
resultsAmong 426 consecutive patients, 74 (17.3%) presented HT (mean age: 65 ± 12 years, number of male patients: 47) on the follow-up scans. In multivariate regression analysis, HT was significantly associated with low GFR (odds ratio [OR] = 3.708, confidence interval [CI] = 1.326-10.693, P = 0.013), atrial fibrillation (AF; OR = 2.444, CI = 1.087-5.356, P = 0.027), large cerebral infarction (OR = 2.583, CI = 1.236-5.262, P = 0.010), and hypoalbuminemia (HA; OR = 4.814, CI = 1.054-22.153, P = 0.037) for AIS patients without TT.
conclusionsThe present study strongly showed that lower GFR is an independently predictor of HT; in addition, large infarct volume, AF, and HA are also important risks of HT for AIS patients without TT, which offered a practical information that risk factors should be paid attention or eliminated to prevent HT for stroke patients though the level of evidence seems to be unstable.
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