Trial reportAnnals of surgical oncology2018
Risk Factors for Postoperative Chylothorax After Radical Subtotal Esophagectomy.
Trial report in Annals of surgical oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Management of chyle leaks following esophageal resection: a systematic review.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2021Pooled it
- A comparative study of indocyanine green instillation in inguinal node versus foot web space using da Vinci indocyanine green FireFly™ technology in identifying thoracic duct during robotic-assisted transthoracic oesophagectomy.Journal of minimal access surgery · 2024Article
- Risk Factors and Treatment of Chylothorax After Minimally Invasive Esophagectomy for Esophageal Cancer.Cureus · 2024Article
- Association between underweight status and chylothorax after esophagectomy for esophageal cancer: A propensity score-matched analysis.JTCVS open · 2024Article
- Clinical Outcomes of Preserving Bronchial Arteries During Radical Esophagectomy: A Propensity-Score Matched Analysis.Annals of surgical oncology · 2024Article
- Postesophagectomy chylothorax: a review of the risk factors, diagnosis, and management.Annals of medicine and surgery (2012) · 2023Article
- Incidence of chylothorax over nineteen years of transhiatal esophagectomy: A case series and review study.Turkish journal of surgery · 2022Article
- Adequate Management of Postoperative Complications after Esophagectomy: A Cornerstone for a Positive Outcome.Cancers · 2022Review
- Lymphatic Interventions in the Cancer Patient.Current oncology reports · 2022Review
- Risk Factors, Diagnosis and Management of Chyle Leak Following Esophagectomy for Cancers: An International Consensus Statement.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2022Article
- Effectiveness of lymphadenectomy along the thoracic duct for radical esophagectomy.Esophagus : official journal of the Japan Esophageal Society · 2022Article
- Clinical impacts of magnetic resonance thoracic ductography on preventing postoperative chylothorax after thoracoscopic esophagectomy for esophageal cancer.Esophagus : official journal of the Japan Esophageal Society · 2021Article
- Management options for post-esophagectomy chylothorax.Surgery today · 2021Review
- Thoracic duct identification with indocyanine green fluorescence during minimally invasive esophagectomy with patient in prone position.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2020Article
- Chyle Leakage after Esophageal Cancer Surgery.The Korean journal of thoracic and cardiovascular surgery · 2020Article
- Prophylactic ligation of the thoracic duct branch prevents chylothorax after pulmonary resection for right lung cancer.Surgery today · 2020Article
- Association between low-fat enteral nutrition after esophagectomy and a lower incidence of chyle leakage: A call for more and better evidence.The Journal of international medical research · 2020Article
- Intranodal lymphangiography for chyle leakage after esophagectomy: A case report.Molecular and clinical oncology · 2020Article
- Risk factors of chylothorax after esophagectomy.Journal of thoracic disease · 2019Article
- Clinical manifestation, risk factors and managements for postoperative chylothorax after thoracic esophagectomy.Journal of thoracic disease · 2019Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChylothorax is one of the complications of esophagectomy for esophageal cancer. The treatment of this condition has been well discussed, but the risk factors for postoperative chylothorax remain unclear.
methodsA retrospective review of 294 patients who underwent esophagectomy for esophageal cancer was conducted. These were patients with squamous cell carcinoma or adenocarcinoma of the esophagus including Siewert type I tumor of the esophagogastric junction who underwent subtotal esophagectomy with two-field or three-field lymphadenectomy. Of these, 24 patients who were diagnosed with chylothorax as a postoperative complication were allocated to the chylothorax group and the other 270 patients were allocated to the nonchylothorax group.
resultsUnivariate analysis showed a significant difference in three factors: resection of thoracic duct, post-chemoradiotherapy, and high intraoperative fluid balance. Multivariate analysis revealed that post-chemoradiotherapy [hazard ratio (HR) = 3.430; 95% confidence interval (CI) 1.364-8.625] and high intraoperative fluid balance (HR = 1.569; 95% CI 1.2.7-2.039) were independent factors predicting chylothorax. In addition, resection of the thoracic duct may be a predictor of chylothorax after esophagectomy (HR = 3.389; 95% CI 0.941-12.201, p = 0.062). Receiver operating characteristic curve analysis of intraoperative fluid revealed that the sensitivity was 62.5%, specificity was 74.1%, and the cutoff value was 6.55 mL/kg/h.
conclusionsThis study revealed that post-chemoradiotherapy and high intraoperative fluid balance are predictors of chylothorax after esophagectomy. The elucidation of clinicopathological factors that can predict the incidence of chylothorax will help to establish more effective perioperative management for esophageal cancer patients.
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