Evidence map›Paper›PMID 29998371›Full record

ReviewNeurosurgical review2020

Recent update on basic mechanisms of spinal cord injury.

Syed A Quadri, Mudassir Farooqui, Asad Ikram, Atif Zafar, Muhammad Adnan Khan, Sajid S Suriya, Chad F Claus, Brian Fiani, Mohammed Rahman, Anirudh Ramachandran and 3 more

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Neurosurgical review, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06553469 (Efficacy of Sacral Nerve Modulation on Urinary and Defecation Dysfunction After Spinal Cord Injury), which is not on this map. Cited by 194 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
194citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06553469 recruitingnot on this mapstarted 2023, after this paper: background citation

Efficacy of Sacral Nerve Modulation on Urinary and Defecation Dysfunction After Spinal Cord Injury

TypeobservationalSponsorQilu Hospital of Shandong UniversityRan2023 to 2025Enrolled41ConditionsCystometry, Sacral Neuromodulation, UltrasoundArmssacral neuromodulation
3 · Its place in the literature

Who cites it

194 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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134 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Syed A QuadriCalifornia Institute of Neuroscience, 2100 Lynn Road, Suite 120, Thousand Oaks, CA, 91360, USA. dr.saqader@gmail.com.ORCID http://orcid.org/0000-0001-7679-1847
Mudassir FarooquiDepartment of Neurology, University of New Mexico, Albuquerque, NM, USA.
Asad IkramDepartment of Neurology, University of New Mexico, Albuquerque, NM, USA.
Atif ZafarDepartment of Neurology, University of New Mexico, Albuquerque, NM, USA.
Muhammad Adnan KhanCalifornia Institute of Neuroscience, 2100 Lynn Road, Suite 120, Thousand Oaks, CA, 91360, USA.
Sajid S SuriyaCalifornia Institute of Neuroscience, 2100 Lynn Road, Suite 120, Thousand Oaks, CA, 91360, USA.
Chad F ClausDepartment of Neurosurgery, St. John Providence Hospital and Medical Centers, Michigan State University, Southfield, MI, USA.
Brian FianiDepartment of Neurosurgery, Desert Regional Medical Center, Palm Springs, CA, USA.
Mohammed RahmanDepartment of Neurology, Desert Regional Medical Center, Palm Springs, CA, USA.
Anirudh RamachandranCollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA, USA.
Ian I T ArmstrongCalifornia Institute of Neuroscience, 2100 Lynn Road, Suite 120, Thousand Oaks, CA, 91360, USA.
Muhammad A TaqiCalifornia Institute of Neuroscience, 2100 Lynn Road, Suite 120, Thousand Oaks, CA, 91360, USA.
Martin M MortazaviCalifornia Institute of Neuroscience, 2100 Lynn Road, Suite 120, Thousand Oaks, CA, 91360, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury (SCI) is a life-shattering neurological condition that affects between 250,000 and 500,000 individuals each year with an estimated two to three million people worldwide living with an SCI-related disability. The incidence in the USA and Canada is more than that in other countries with motor vehicle accidents being the most common cause, while violence being most common in the developing nations. Its incidence is two- to fivefold higher in males, with a peak in younger adults. Apart from the economic burden associated with medical care costs, SCI predominantly affects a younger adult population. Therefore, the psychological impact of adaptation of an average healthy individual as a paraplegic or quadriplegic with bladder, bowel, or sexual dysfunction in their early life can be devastating. People with SCI are two to five times more likely to die prematurely, with worse survival rates in low- and middle-income countries. This devastating disorder has a complex and multifaceted mechanism. Recently, a lot of research has been published on the restoration of locomotor activity and the therapeutic strategies. Therefore, it is imperative for the treating physicians to understand the complex underlying pathophysiological mechanisms of SCI.

Indexed as

AdultAgedDisease ProgressionHumansIncidenceMiddle AgedSpinal Cord InjuriesYoung AdultChronic phaseMechanism of spinal cord injuryPrimary phaseSecondary phaseSpinal cord injury

Identifiers

PMID29998371

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.