ArticlePsychopharmacology2018
Dual contributions of noradrenaline to behavioural flexibility and motivation.
Article in Psychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 59 citations in OpenAlex.
- Acetylcholine and noradrenaline enhance foraging optimality in humans.Proceedings of the National Academy of Sciences of the United States of America · 2023Trial
- Disentangling the roles of dopamine and noradrenaline in the exploration-exploitation tradeoff during human decision-making.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- Regulation of the decision threshold by the locus coeruleus.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Arousal shapes motivation: an integrative framework for understanding motivational deficits.Translational psychiatry · 2026Review
- Insights into effortful adaptation during speech perception: The role of dopamine, norepinephrine, and prediction error.Cognitive, affective & behavioral neuroscience · 2026Review
- Clonidine for Management of Agitation in Delirious Patients.Current psychiatry reports · 2025Review
- Adrenergic Modulation of Cortical Gain and Sensory Processing in the Mouse Visual Cortex.Brain sciences · 2025Article
- α1 Adrenergic Receptors Mediate Panic-like Defensive Behavior in Alcohol-Drinking but Not Alcohol-Naïve Rats.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Frontal noradrenergic and cholinergic transients exhibit distinct spatiotemporal dynamics during competitive decision-making.Science advances · 2025Article
- Playful brains: a possible neurobiological pathway to cognitive health in aging.Frontiers in human neuroscience · 2025Article
- The Projection-Specific Noradrenergic Modulation of Perseverative Spatial Behavior in Adult Male Rats.eNeuro · 2024Article
- Adaptive Responding to Stimulus-Outcome Associations Requires Noradrenergic Transmission in the Medial Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Exploring distinct and joint contributions of the locus coeruleus and the substantia nigra/ventral tegmental area complex to reward and valence processing using high-resolution fMRI.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Amphetamines Improve the Motivation to Invest Effort in Attention-Deficit/Hyperactivity Disorder.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Neural responses in macaque prefrontal cortex are linked to strategic exploration.PLoS biology · 2023Article
- Commentary: AlphaFrontiers in behavioral neuroscience · 2023Article
- Using Inhibitory DREADDs to Silence LC Neurons in Monkeys.Brain sciences · 2022Article
- Regulation of cocaine seeking behavior by locus coeruleus noradrenergic activity in the ventral tegmental area is time- and contingency-dependent.Frontiers in neuroscience · 2022Article
- Different depression: motivational anhedonia governs antidepressant efficacy in Huntington's disease.Brain communications · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
introductionWhile several theories have highlighted the importance of the noradrenergic system for behavioral flexibility, a number of recent studies have also shown a role for noradrenaline in motivation, particularly in effort processing. Here, we designed a novel sequential cost/benefit decision task to test the causal influence of noradrenaline on these two functions in rhesus monkeys.
methodsWe manipulated noradrenaline using clonidine, an alpha-2 noradrenergic receptor agonist, which reduces central noradrenaline levels and examined how this manipulation influenced performance on the task.
resultsClonidine had two specific and distinct effects: first, it decreased choice variability, without affecting the cost/benefit trade-off; and second, it reduced force production, without modulating the willingness to work.
conclusionsTogether, these results support an overarching role for noradrenaline in facing challenging situations in two complementary ways: by modulating behavioral volatility, which would facilitate adaptation depending on the lability of the environment, and by modulating the mobilization of resources to face immediate challenges.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.