Bilateral exudative retinal detachments due to thrombotic microangiopathy associated with intravenous abuse of Opana ER.

Fazila Aseem, Brian G Zamora, Levi Kauffman, Peter J Miller, Vishak J John

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Article in American journal of ophthalmology case reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

0.3field-weighted citation impact, top 44% of its field

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0 citing papers in PubMed, 4 citations in OpenAlex.

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5 · Who and what money

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5 authors at 1 institution in 1 country.

Fazila AseemDepartment of Ophthalmology, Wake Forest School of Medicine, 1 Medical Center Blvd, Winston-Salem, NC 27157, USA.

Brian G ZamoraDepartment of Ophthalmology, Wake Forest School of Medicine, 1 Medical Center Blvd, Winston-Salem, NC 27157, USA.

Levi KauffmanDepartment of Ophthalmology, Wake Forest School of Medicine, 1 Medical Center Blvd, Winston-Salem, NC 27157, USA.

Peter J MillerDepartment of Internal Medicine, Sections on Hematology and Oncology, and Pulmonary, Critical Care, Allergy and Immunologic Medicine, Department of Anesthesia, Section on Critical Care, Wake Forest School of Medicine, 1 Medical Center Blvd, Winston-Salem, NC 27157, USA.

Vishak J JohnDepartment of Ophthalmology, Wake Forest School of Medicine, 1 Medical Center Blvd, Winston-Salem, NC 27157, USA.

Wake Forest University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo report the only known case, to our knowledge, of bilateral exudative retinal detachments in the setting of thrombotic microangiopathy associated with intravenous abuse of extended-release oxymorphone (Opana ER). OBSERVATIONS: A 35-year-old male presented with headaches and acute, painless vision loss in the context of daily IV abuse of crushed oral Opana ER. The patient was found to have microangiopathic hemolytic anemia (MAHA), acute kidney injury in conjunction with hypertensive crisis and bilateral exudative retinal detachments. CONCLUSIONS AND IMPORTANCE: Bilateral exudative retinal detachments are rare ophthalmic complications that have been reported with thrombotic thrombocytopenic purpura (TTP). Non-TTP thrombotic microangiopathy, initially described as a "TTP-like illness" consisting of MAHA and thrombocytopenia, has been associated with the IV abuse of Opana ER. We report a case of bilateral exudative retinal detachments due to thrombotic microangiopathy in the setting of IV abuse of Opana ER.

Indexed as

Bilateral exudative retinal detachmentDrug-induced thrombotic microangiopathyOpana EROpioid drug abuse

Identifiers

PMID29998206

DOI10.1016/j.ajoc.2018.06.001

PMCPMC6038103

OpenAlexW2807525416

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.