Evidence map›Paper›PMID 29997796›Full record

ArticleChemical science2016

Multi-scale imaging of anticancer platinum(iv) compounds in murine tumor and kidney.

A A Legin, S Theiner, A Schintlmeister, S Reipert, P Heffeter, M A Jakupec, J Mayr, H P Varbanov, C R Kowol, M Galanski and 3 more

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.9field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 38 citations in OpenAlex.

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  11. An anticancer gold(III)-activated porphyrin scaffold that covalently modifies protein cysteine thiols.Proceedings of the National Academy of Sciences of the United States of America · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

A A LeginInstitute of Inorganic Chemistry , Research Platform "Translational Cancer Therapy Research," and Research Network "Chemistry meets Microbiology" , University of Vienna , Währinger Straße 42 , A-1090 Vienna , Austria . Email: bernhard.keppler@univie.ac.at ; Tel: +43-1-4277-52600.
S TheinerInstitute of Inorganic Chemistry , Research Platform "Translational Cancer Therapy Research," and Research Network "Chemistry meets Microbiology" , University of Vienna , Währinger Straße 42 , A-1090 Vienna , Austria . Email: bernhard.keppler@univie.ac.at ; Tel: +43-1-4277-52600.
A SchintlmeisterDepartment of Microbiology and Ecosystem Science , Research Network "Chemistry meets Microbiology", and Large-Instrument Facility for Advanced Isotope Research , University of Vienna , A-1090 Vienna , Austria.
S ReipertCore Facility of Cell Imaging and Ultrastructure Research , University of Vienna , A-1090 Vienna , Austria.
P HeffeterInstitute of Cancer Research , Comprehensive Cancer Center and Research Platform "Translational Cancer Therapy Research" , Medical University of Vienna , A-1090 Vienna , Austria.
M A JakupecInstitute of Inorganic Chemistry , Research Platform "Translational Cancer Therapy Research," and Research Network "Chemistry meets Microbiology" , University of Vienna , Währinger Straße 42 , A-1090 Vienna , Austria . Email: bernhard.keppler@univie.ac.at ; Tel: +43-1-4277-52600.
J MayrInstitute of Inorganic Chemistry , Research Platform "Translational Cancer Therapy Research," and Research Network "Chemistry meets Microbiology" , University of Vienna , Währinger Straße 42 , A-1090 Vienna , Austria . Email: bernhard.keppler@univie.ac.at ; Tel: +43-1-4277-52600.
H P VarbanovInstitute of Inorganic Chemistry , Research Platform "Translational Cancer Therapy Research," and Research Network "Chemistry meets Microbiology" , University of Vienna , Währinger Straße 42 , A-1090 Vienna , Austria . Email: bernhard.keppler@univie.ac.at ; Tel: +43-1-4277-52600.
C R KowolInstitute of Inorganic Chemistry , Research Platform "Translational Cancer Therapy Research," and Research Network "Chemistry meets Microbiology" , University of Vienna , Währinger Straße 42 , A-1090 Vienna , Austria . Email: bernhard.keppler@univie.ac.at ; Tel: +43-1-4277-52600.
M GalanskiInstitute of Inorganic Chemistry , Research Platform "Translational Cancer Therapy Research," and Research Network "Chemistry meets Microbiology" , University of Vienna , Währinger Straße 42 , A-1090 Vienna , Austria . Email: bernhard.keppler@univie.ac.at ; Tel: +43-1-4277-52600.
W BergerInstitute of Cancer Research , Comprehensive Cancer Center and Research Platform "Translational Cancer Therapy Research" , Medical University of Vienna , A-1090 Vienna , Austria.ORCID 0000-0003-0014-1658
M WagnerDepartment of Microbiology and Ecosystem Science , Research Network "Chemistry meets Microbiology", and Large-Instrument Facility for Advanced Isotope Research , University of Vienna , A-1090 Vienna , Austria.ORCID 0000-0002-9778-7684
B K KepplerInstitute of Inorganic Chemistry , Research Platform "Translational Cancer Therapy Research," and Research Network "Chemistry meets Microbiology" , University of Vienna , Währinger Straße 42 , A-1090 Vienna , Austria . Email: bernhard.keppler@univie.ac.at ; Tel: +43-1-4277-52600.
University of Vienna · ATComprehensive Cancer Center Vienna · AT

Funding

Austrian Science Fund FWF P 27749European Research Council 294343
6 · The paper itself

Abstract

Nano-scale secondary ion mass spectrometry (NanoSIMS) enables trace element and isotope analyses with high spatial resolution. This unique capability has recently been exploited in several studies analyzing the subcellular distribution of Au and Pt anticancer compounds. However, these studies were restricted to cell culture systems. To explore the applicability to the

Identifiers

PMID29997796
PMCPMC6004953
OpenAlexW2272593792

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.