Evidence map›Paper›PMID 29997518›Full record

ArticleFrontiers in physiology2018

Impaired Myofilament Contraction Drives Right Ventricular Failure Secondary to Pressure Overload: Model Simulations, Experimental Validation, and Treatment Predictions.

Jennifer L Philip, Ryan J Pewowaruk, Claire S Chen, Diana M Tabima, Daniel A Beard, Anthony J Baker, Naomi C Chesler

Abstract read
In one paragraph

Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Reversal of right ventricular failure by chronic αAmerican journal of physiology. Heart and circulatory physiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jennifer L PhilipDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States.
Ryan J PewowarukDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States.
Claire S ChenDepartment of Mechanical Engineering, University of Wisconsin-Madison, Madison, WI, United States.
Diana M TabimaDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States.
Daniel A BeardDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
Anthony J BakerSan Francisco Veterans Affairs Medical Center, San Francisco, CA, United States.
Naomi C CheslerDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States.

Funding

Integrated Modeling of Cardiac Metabolism and TransportR01HL072011 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BEARD, DANIEL A · 2004 to 2016
$4.0M
Vascular collagen accumulation & mechanical mechanisms in pulmonary hypertensionR01HL086939 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI CHESLER, NAOMI C · 2007 to 2016
$3.6M
Vascular Surgery Research Training ProgramT32HL110853 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI MATSUMURA, JON STEVEN · 2012 to 2021
$2.6M
Right Heart Function in Health and Chronic Lung DiseaseI01BX000740 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI Anthony J. BAKER · 2011 to 2026
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BLRD VA I01 BX000740NHLBI NIH HHS R01 HL072011NHLBI NIH HHS R01 HL086939NHLBI NIH HHS T32 HL110853
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

computational modelingfibrosismyocyte force generationmyoycte mechanicspulmonary hypertensionright ventricleright ventricular failure

Identifiers

PMID29997518
PMCPMC6030352

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.