ArticleClinical epidemiology2018
Trends in treatments of thyroid disease following iodine fortification in Denmark: a nationwide register-based study.
Article in Clinical epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- The Influence of Nutritional Intervention in the Treatment of Hashimoto's Thyroiditis-A Systematic Review.Nutrients · 2023Pooled it
- Trends in the use of thyroid diagnostics and treatments between 2008 and 2019 in Germany.Scientific reports · 2024Article
- The Danish investigation on iodine intake and thyroid disease (DanThyr): history and implications.European thyroid journal · 2024Review
- Risk-Benefit Assessment of an Increase in the Iodine Fortification Level of Foods in Denmark-A Pilot Study.Foods (Basel, Switzerland) · 2022Article
- Register-based information on thyroid diseases in Europe: lessons and results from the EUthyroid collaboration.Endocrine connections · 2022Article
- Estimation of the prevalence of thyroid dysfunction in Catalonia through two different registries: Pharmaceutical dispensing and diagnostic registration.Endocrinology, diabetes & metabolism · 2021Article
- Geographic influences in the global rise of thyroid cancer.Nature reviews. Endocrinology · 2020Review
- Association between serum TSH levels and metabolic components in euthyroid subjects: a nationwide population-based study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLong-term iodine exposure may influence the frequency of thyroid disease treatments through fluctuations in thyroid diseases. Yet, the long-term fluctuations in thyroid disease treatments upon iodine fortification (IF) are not fully known. We aimed to examine the development in thyroid disease treatments in Denmark before and following the implementation of IF in 2000.
methodsNationwide data on antithyroid medication, thyroid hormone therapy, thyroid surgery, and radioiodine treatment were obtained from Danish registries. Negative binominal regression was applied to analyze annual changes in treatment rates adjusted for region of residence, sex, and age.
resultsIncidence of antithyroid medication transiently increased but fell and reached steady state from 2010 at an incidence rate ratio (RR) of 0.72 (95% confidence interval [CI] 0.67-0.77) compared to year 2000. Thyroid hormone therapy increased and reached steady state in 2010 at an incidence RR of 1.75 (95% CI 1.62-1.89) compared to year 2000. Thyroid surgery was constant except for higher rates in 2014-2015, and radioiodine treatment fluctuated with no apparent pattern.
conclusionTen years after IF, a steady state was observed for incident antithyroid medication below the level at IF, and thyroid hormone therapy above the level at IF. Only small changes were observed in thyroid surgery and radioiodine treatment. In the same period, changes in diagnostic and treatment practices and lifestyle factors are likely to have occurred and should be considered when evaluating the effects of IF on treatment of thyroid diseases.
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