Evidence map›Paper›PMID 29997263›Full record

ArticleRNA (New York, N.Y.)2018

Translation elongation and mRNA stability are coupled through the ribosomal A-site.

Gavin Hanson, Najwa Alhusaini, Nathan Morris, Thomas Sweet, Jeff Coller

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Enhancement of Therapeutic mRNA Translation in Cellular Stress Conditions.International journal of molecular sciences · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Tailor made: the art of therapeutic mRNA design.Nature reviews. Drug discovery · 2024
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Gavin Hanson *Center for RNA Science and Therapeutics, Case Western Reserve University, Cleveland, Ohio 44106, USA.
Najwa Alhusaini *Center for RNA Science and Therapeutics, Case Western Reserve University, Cleveland, Ohio 44106, USA.
Nathan MorrisStatistical Science Core, Case Western Reserve University, Cleveland, Ohio 44106, USA.
Thomas SweetCenter for RNA Science and Therapeutics, Case Western Reserve University, Cleveland, Ohio 44106, USA.
Jeff CollerCenter for RNA Science and Therapeutics, Case Western Reserve University, Cleveland, Ohio 44106, USA.ORCID 0000-0001-5662-8110
Case Western Reserve University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
Understanding the Interconnection Between mRNA turnover and mRNA TranslationR01GM125086 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI COLLER, JEFFERY · 2017 to 2020
$1.6M
Determining the influence of codon optimality on mRNA translation and decayR01GM118018 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI COLLER, JEFFERY · 2017 to 2020
$1.3M
NIGMS NIH HHS R01 GM118018NIGMS NIH HHS R01 GM125086NIGMS NIH HHS T32 GM007250
6 · The paper itself

Abstract

Messenger RNA (mRNA) degradation plays a critical role in regulating transcript levels in eukaryotic cells. Previous work by us and others has shown that codon identity exerts a powerful influence on mRNA stability. In

Indexed as

Binding SitesCodonProtein BindingProtein BiosynthesisRibosomesRNA, MessengerRNA Processing, Post-TranscriptionalRNA StabilitySaccharomyces cerevisiaeCodonRNA, Messengercodon optimalitydecodingmRNA decaytranslation elongation

Identifiers

PMID29997263
PMCPMC6140462
OpenAlexW2951442170

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.