Evidence map›Paper›PMID 29997258›Full record

ArticleJournal of the Royal Society, Interface2018

Noise control for molecular computing.

Tomislav Plesa, Konstantinos C Zygalakis, David F Anderson, Radek Erban

Abstract read
In one paragraph

Article in Journal of the Royal Society, Interface, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Chemical Systems with Limit Cycles.Bulletin of mathematical biology · 2023
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tomislav PlesaMathematical Institute, University of Oxford, Andrew Wiles Building, Radcliffe Observatory Quarter, Woodstock Road, Oxford, UK.
Konstantinos C ZygalakisSchool of Mathematics, University of Edinburgh, Maxwell Building, Peter Guthrie Tait Road, Edinburgh, UK.
David F AndersonDepartment of Mathematics, University of Wisconsin-Madison, Lincoln Drive, Madison, WI, USA.
Radek ErbanMathematical Institute, University of Oxford, Andrew Wiles Building, Radcliffe Observatory Quarter, Woodstock Road, Oxford, UK erban@maths.ox.ac.uk.ORCID 0000-0001-8470-3763

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synthetic biology is a growing interdisciplinary field, with far-reaching applications, which aims to design biochemical systems that behave in a desired manner. With the advancement in nucleic-acid-based technology in general, and strand-displacement DNA computing in particular, a large class of abstract biochemical networks may be physically realized using nucleic acids. Methods for systematic design of the abstract systems with prescribed behaviours have been predominantly developed at the (less-detailed) deterministic level. However, stochastic effects, neglected at the deterministic level, are increasingly found to play an important role in biochemistry. In such circumstances, methods for controlling the intrinsic noise in the system are necessary for a successful network design at the (more-detailed) stochastic level. To bridge the gap, the

Indexed as

AlgorithmsSignal-To-Noise RatioSynthetic BiologyComputers, MolecularStochastic Processesbiochemical engineeringchemical reaction networksintrinsic noisemolecular/DNA computingstochastic dynamical systemssynthetic biology

Identifiers

PMID29997258
PMCPMC6073653

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.