Evidence map›Paper›PMID 29997255›Full record

ArticleThe Journal of biological chemistry2018

PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2.

Muriel Desbois, Oliver Crawley, Paul R Evans, Scott T Baker, Ikuo Masuho, Ryohei Yasuda, Brock Grill

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 49 citations in OpenAlex.

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  20. SARM1 can be a potential therapeutic target for spinal cord injury.Cellular and molecular life sciences : CMLS · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Muriel DesboisFrom the Department of Neuroscience, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458 and.
Oliver CrawleyFrom the Department of Neuroscience, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458 and.
Paul R Evansthe Max Planck Florida Institute for Neuroscience, Jupiter, Florida 33458.
Scott T BakerFrom the Department of Neuroscience, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458 and.
Ikuo MasuhoFrom the Department of Neuroscience, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458 and.
Ryohei Yasudathe Max Planck Florida Institute for Neuroscience, Jupiter, Florida 33458.
Brock GrillFrom the Department of Neuroscience, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458 and bgrill@scripps.edu.ORCID 0000-0002-0379-3267
Scripps Research Institute · USMax Planck Florida Institute for Neuroscience · US

Funding

Mechanisms of synapse formation and axon termination in C. elegansR01NS072129 · NINDS · UNIVERSITY OF MINNESOTA · PI GRILL, BROCK · 2011 to 2024
$8.0M
NINDS NIH HHS R01 NS072129
6 · The paper itself

Abstract

PHR (

Indexed as

UbiquitinationAdaptor Proteins, Signal TransducingAmidine-LyasesAnimalsCaenorhabditis elegansF-Box ProteinsHumansMixed Function OxygenasesMultiprotein ComplexesNicotinamide-Nucleotide AdenylyltransferaseProtein BindingSKP Cullin F-Box Protein LigasesS-Phase Kinase-Associated ProteinsUbiquitin-Protein LigasesAdaptor Proteins, Signal TransducingAmidine-LyasesF-Box ProteinsFBXO45 protein, humanMixed Function OxygenasesMultiprotein ComplexesMYCBP2 protein, humanNicotinamide-Nucleotide AdenylyltransferaseNMNAT2 protein, humanPAM protein, humanSKP1 protein, humanSKP Cullin F-Box Protein LigasesS-Phase Kinase-Associated ProteinsUbiquitin-Protein Ligasesaxonaxon degenerationCaenorhabditis elegans (C. elegans)E3 ubiquitin ligaseF-boxFBXO45fluorescence resonance energy transfer (FRET)FSN-1MYCBP2neurodegenerationneuronNMNATPAMPHR proteinproteasomeRPM-1ubiquitinationubiquitin ligase

Identifiers

PMID29997255
PMCPMC6130950
OpenAlexW2820382592

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.