Evidence map›Paper›PMID 29997242›Full record

ArticleBiology open2018

Ectopic otoconial formation in the lagena of the pigeon inner ear.

E Pascal Malkemper, Matthew J Mason, Daniel Kagerbauer, Simon Nimpf, David A Keays

Abstract read
In one paragraph

Article in Biology open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Otolithic organs and vibratory sensitivity in frogs: do saccular otoconial volumes vary according to lifestyle?Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026
    Review
  2. Nox3-Derived Superoxide in Cochleae Induces Sensorineural Hearing Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

E Pascal MalkemperResearch Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Campus Vienna Biocenter 1, Vienna 1030, Austria keays@imp.ac.at erich.malkemper@imp.ac.at.ORCID http://orcid.org/0000-0003-1099-0119
Matthew J MasonUniversity of Cambridge, Department of Physiology, Development & Neuroscience, Downing Street, Cambridge CB2 3EG, UK.ORCID http://orcid.org/0000-0001-7845-0720
Daniel KagerbauerTU Wien, Atominstitut, Stadionallee 2, 1020 Vienna, Austria.
Simon NimpfResearch Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Campus Vienna Biocenter 1, Vienna 1030, Austria.
David A KeaysResearch Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Campus Vienna Biocenter 1, Vienna 1030, Austria keays@imp.ac.at erich.malkemper@imp.ac.at.ORCID http://orcid.org/0000-0002-8343-8002

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The vertebrate inner ear contains vestibular receptors with dense crystals of calcium carbonate, the otoconia. The production and maintenance of otoconia is a delicate process, the perturbation of which can lead to severe vestibular dysfunction in humans. The details of these processes are not well understood. Here, we report the discovery of a new otoconial mass in the lagena of adult pigeons that was present in more than 70% of birds. Based on histological, tomographic and elemental analyses, we conclude that the structure likely represents an ectopically-formed otoconial assembly. Given its frequent natural occurrence, we suggest that the pigeon lagena is a valuable model system for investigating misregulated otoconial formation.This article has an associated First Person interview with the first author of the paper.

Indexed as

Avian lagenaDark cellsInner earMagnetoreceptionOtolithTegmentum vasculosumVestibular organs

Identifiers

PMID29997242
PMCPMC6124575

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.