Evidence map›Paper›PMID 29997225›Full record

ArticleCirculation. Genomic and precision medicine2018

Rho Guanine Nucleotide Exchange Factor

Xinyu Yang, Jiani Li, Yabo Fang, Zhen Zhang, Daqing Jin, Xingdong Chen, Yan Zhao, Mengqi Li, Linchun Huan, Thomas A Kent and 7 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Genomic and precision medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Biology, Physics, and Genetics of Intracranial Aneurysm Formation: A Review.Journal of neurological surgery. Part A, Central European neurosurgery · 2026
    Review
  3. Article
  4. Case report: Expanding the phenotype ofFrontiers in neurology · 2022
    Article
  5. Article
  6. Review
  7. Article
  8. A Rare Variant ofFrontiers in neurology · 2021
    Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Rare and Low-Frequency Variant ofCirculation. Genomic and precision medicine · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Xinyu YangDepartment of Neurosurgery, Tianjin Neurological Institute, Tianjin Medical University General Hospital, China (X.Y., Z.Z., Y.Z., M.L., L.H., R.J., S.Y., J.Z., F.Y.).
Jiani LiHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX (J.L., F.Y.).
Yabo FangState Key Laboratory of Genetic Engineering, School of Life Sciences, Zhong Shan Hospital, Fudan University, Shanghai, China (Y.F., D.J., X.C., L.J., T.P.Z.).
Zhen ZhangDepartment of Neurosurgery, Tianjin Neurological Institute, Tianjin Medical University General Hospital, China (X.Y., Z.Z., Y.Z., M.L., L.H., R.J., S.Y., J.Z., F.Y.).
Daqing JinState Key Laboratory of Genetic Engineering, School of Life Sciences, Zhong Shan Hospital, Fudan University, Shanghai, China (Y.F., D.J., X.C., L.J., T.P.Z.).
Xingdong ChenState Key Laboratory of Genetic Engineering, School of Life Sciences, Zhong Shan Hospital, Fudan University, Shanghai, China (Y.F., D.J., X.C., L.J., T.P.Z.).
Yan ZhaoDepartment of Neurosurgery, Tianjin Neurological Institute, Tianjin Medical University General Hospital, China (X.Y., Z.Z., Y.Z., M.L., L.H., R.J., S.Y., J.Z., F.Y.).
Mengqi LiDepartment of Neurosurgery, Tianjin Neurological Institute, Tianjin Medical University General Hospital, China (X.Y., Z.Z., Y.Z., M.L., L.H., R.J., S.Y., J.Z., F.Y.).
Linchun HuanDepartment of Neurosurgery, Tianjin Neurological Institute, Tianjin Medical University General Hospital, China (X.Y., Z.Z., Y.Z., M.L., L.H., R.J., S.Y., J.Z., F.Y.).
Thomas A KentEngineering Medicine, Texas A&M Health Science Center and College of Engineering, Houston (T.A.K.).
Jing-Fei DongBlood Works Northwest Research Institute, Seattle, WA (J.-F.D.).
Rongcai JiangDepartment of Neurosurgery, Tianjin Neurological Institute, Tianjin Medical University General Hospital, China (X.Y., Z.Z., Y.Z., M.L., L.H., R.J., S.Y., J.Z., F.Y.).
Shuyuan YangDepartment of Neurosurgery, Tianjin Neurological Institute, Tianjin Medical University General Hospital, China (X.Y., Z.Z., Y.Z., M.L., L.H., R.J., S.Y., J.Z., F.Y.).
Li JinState Key Laboratory of Genetic Engineering, School of Life Sciences, Zhong Shan Hospital, Fudan University, Shanghai, China (Y.F., D.J., X.C., L.J., T.P.Z.).
Jianning ZhangDepartment of Neurosurgery, Tianjin Neurological Institute, Tianjin Medical University General Hospital, China (X.Y., Z.Z., Y.Z., M.L., L.H., R.J., S.Y., J.Z., F.Y.). fyu@bcm.edu taozhong@fudan.edu.cn jianningzhang@hotmail.com.
Tao P ZhongState Key Laboratory of Genetic Engineering, School of Life Sciences, Zhong Shan Hospital, Fudan University, Shanghai, China (Y.F., D.J., X.C., L.J., T.P.Z.). fyu@bcm.edu taozhong@fudan.edu.cn jianningzhang@hotmail.com.
Fuli YuDepartment of Neurosurgery, Tianjin Neurological Institute, Tianjin Medical University General Hospital, China (X.Y., Z.Z., Y.Z., M.L., L.H., R.J., S.Y., J.Z., F.Y.). fyu@bcm.edu taozhong@fudan.edu.cn jianningzhang@hotmail.com.
University of Washington · US

Funding

Novel Carbon Nanozyme Mechanisms for Traumatic Brain InjuryR01NS094535 · NINDS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI HEGDE, MURALIDHAR L, KENT, THOMAS · 2015 to 2024
$4.1M
VWF Activity: Molecular Biology, Ethnic Diversity and Disease AssociationsR01HL125957 · NHLBI · BLOODWORKS · PI DONG, JING-FEI, YU, FULI · 2015 to 2018
$2.5M
Next-Generation Bioinformatics for Next-Generation SequencingR01HG008115 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI YU, FULI, ZHANG, KUI · 2014 to 2016
$1.4M
NHGRI NIH HHS R01 HG008115NHLBI NIH HHS R01 HL125957NINDS NIH HHS R01 NS094535
6 · The paper itself

Abstract

backgroundIntracranial aneurysm (IA) is usually a late-onset disease, affecting 1% to 3% of the general population and leading to life-threatening subarachnoid hemorrhage. Genetic susceptibility has been implicated in IAs, but the causative genes remain elusive.

methodsWe performed next-generation sequencing in a discovery cohort of 20 Chinese IA patients. Bioinformatics filters were exploited to search for candidate deleterious variants with rare and low allele frequency. We further examined the candidate variants in a multiethnic sample collection of 86 whole exome sequenced unsolved familial IA cases from 3 previously published studies.

resultsWe identified that the low-frequency variant c.4394C>A_p.Ala1465Asp (rs2298808) of

conclusionsOur results provide compelling evidence that

Indexed as

ExomeGenetic Predisposition to DiseaseAdultAllelesCanadaCohort StudiesFemaleGene FrequencyHumansIntracranial AneurysmMaleMiddle AgedRho Guanine Nucleotide Exchange FactorsRisk FactorsSubarachnoid HemorrhageARHGEF17 protein, humanRho Guanine Nucleotide Exchange Factorsgenomicshemorrhagehuman geneticsintracranial aneurysmsubarachnoidzebrafish

Identifiers

PMID29997225
PMCPMC6141028
OpenAlexW2896604185

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.