Evidence map›Paper›PMID 29997220›Full record

ArticleDisease models & mechanisms2018

Intravital microscopy of collective invasion plasticity in breast cancer.

Olga Ilina, Leonard Campanello, Pavlo G Gritsenko, Manon Vullings, Chenlu Wang, Peter Bult, Wolfgang Losert, Peter Friedl

Open access · goldAbstract read
In one paragraph

Article in Disease models & mechanisms, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 78 citations in OpenAlex.

  1. Article
  2. Review
  3. Amoeboid-mesenchymal transition and the proteolytic control of cancer invasion plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Article
  6. Mechanical signatures in cancer metastasis.npj biological physics and mechanics · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Multidimensional Imaging of Breast Cancer.Cold Spring Harbor perspectives in medicine · 2023
    Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Olga IlinaDepartment of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, PO Box 9101, 6500HB, Nijmegen, The Netherlands.
Leonard CampanelloDepartment of Physics, Institute for Physical Science and Technology, University of Maryland, College Park, MD 20742, USA.
Pavlo G GritsenkoDepartment of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, PO Box 9101, 6500HB, Nijmegen, The Netherlands.
Manon VullingsDepartment of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, PO Box 9101, 6500HB, Nijmegen, The Netherlands.
Chenlu WangDepartment of Physics, Institute for Physical Science and Technology, University of Maryland, College Park, MD 20742, USA.
Peter BultDepartment of Pathology, Radboud University Medical Center, PO Box 9101, 6500HB, Nijmegen, The Netherlands.
Wolfgang LosertDepartment of Physics, Institute for Physical Science and Technology, University of Maryland, College Park, MD 20742, USA.
Peter FriedlDepartment of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, PO Box 9101, 6500HB, Nijmegen, The Netherlands peter.friedl@radboudumc.nl.ORCID 0000-0002-0119-4041
Radboud University Nijmegen · NLUniversity of Maryland, College Park · USThe University of Texas MD Anderson Cancer Center · US

Funding

Project 3: Physical and Metabolic Constraints of Cancer Cell InvasionU54CA210184 · NCI · CORNELL UNIVERSITY · PI ZIPFEL, WARREN R · 2016 to 2020
$10.2M
Elucidating TCR signaling mechanisms via quantitative pattern analysis_administrative supplementU01GM109887 · NIGMS · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI LOSERT, WOLFGANG, SCHAEFER, BRIAN · 2014 to 2017
$1.1M
NCI NIH HHS U54 CA210184NIGMS NIH HHS U01 GM109887
6 · The paper itself

Abstract

Cancer invasion programs are adaptive by switching between metastatic collective and single-cell dissemination; however, current intravital microscopy models for epithelial cancer in mice fail to reliably recreate such invasion plasticity. Using microimplantation of breast cancer spheroids into the murine mammary fat pad and live-cell monitoring, we show microenvironmental conditions and cytoskeletal adaptation during collective to single-cell transition

Indexed as

Cell PlasticityIntravital MicroscopyActinsAnimalsCell Line, TumorCell ProliferationFemaleHEK293 CellsHumansImaging, Three-DimensionalMammary Neoplasms, AnimalMice, Inbred BALB CNeoplasm InvasivenessNeoplasm MetastasisNeovascularization, PathologicStromal CellsActinsActin dynamicsCarcinoma invasionIntravital microscopy

Identifiers

PMID29997220
PMCPMC6176993
OpenAlexW2838855305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.