Evidence map›Paper›PMID 29997190›Full record

ArticleNeurology2018

Late-life blood pressure association with cerebrovascular and Alzheimer disease pathology.

Zoe Arvanitakis, Ana W Capuano, Melissa Lamar, Raj C Shah, Lisa L Barnes, David A Bennett, Julie A Schneider

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 4 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 4 syntheses or guidelines pooled it, 111 citations in OpenAlex.

  1. Pooled it
  2. Hypertension and Alzheimer's disease pathology at autopsy: A systematic review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Article
  7. Hypertension acts together with Aβ pathology in late-life to promote memory loss.The journal of prevention of Alzheimer's disease · 2026
    Article
  8. Article
  9. Article
  10. Cardiovascular contributions to dementia: Examining sex differences and female-specific factors.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  11. Article
  12. Article
  13. Hypertension and cerebral blood flow in the development of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zoe ArvanitakisFrom the Rush Alzheimer's Disease Center (Z.A., A.W.C., M.L., R.C.S., L.L.B., D.A.B., J.A.S.), and Departments of Neurological Sciences (Z.A., A.W.C., M.L., L.L.B., D.A.B., J.A.S.), Family Medicine (R.C.S.), Behavioral Sciences (L.L.B.), and Pathology (J.A.S.), Rush University Medical Center, Chicago, IL. zarvanit@rush.edu.
Ana W CapuanoFrom the Rush Alzheimer's Disease Center (Z.A., A.W.C., M.L., R.C.S., L.L.B., D.A.B., J.A.S.), and Departments of Neurological Sciences (Z.A., A.W.C., M.L., L.L.B., D.A.B., J.A.S.), Family Medicine (R.C.S.), Behavioral Sciences (L.L.B.), and Pathology (J.A.S.), Rush University Medical Center, Chicago, IL.
Melissa LamarFrom the Rush Alzheimer's Disease Center (Z.A., A.W.C., M.L., R.C.S., L.L.B., D.A.B., J.A.S.), and Departments of Neurological Sciences (Z.A., A.W.C., M.L., L.L.B., D.A.B., J.A.S.), Family Medicine (R.C.S.), Behavioral Sciences (L.L.B.), and Pathology (J.A.S.), Rush University Medical Center, Chicago, IL.
Raj C ShahFrom the Rush Alzheimer's Disease Center (Z.A., A.W.C., M.L., R.C.S., L.L.B., D.A.B., J.A.S.), and Departments of Neurological Sciences (Z.A., A.W.C., M.L., L.L.B., D.A.B., J.A.S.), Family Medicine (R.C.S.), Behavioral Sciences (L.L.B.), and Pathology (J.A.S.), Rush University Medical Center, Chicago, IL.
Lisa L BarnesFrom the Rush Alzheimer's Disease Center (Z.A., A.W.C., M.L., R.C.S., L.L.B., D.A.B., J.A.S.), and Departments of Neurological Sciences (Z.A., A.W.C., M.L., L.L.B., D.A.B., J.A.S.), Family Medicine (R.C.S.), Behavioral Sciences (L.L.B.), and Pathology (J.A.S.), Rush University Medical Center, Chicago, IL.
David A BennettFrom the Rush Alzheimer's Disease Center (Z.A., A.W.C., M.L., R.C.S., L.L.B., D.A.B., J.A.S.), and Departments of Neurological Sciences (Z.A., A.W.C., M.L., L.L.B., D.A.B., J.A.S.), Family Medicine (R.C.S.), Behavioral Sciences (L.L.B.), and Pathology (J.A.S.), Rush University Medical Center, Chicago, IL.
Julie A SchneiderFrom the Rush Alzheimer's Disease Center (Z.A., A.W.C., M.L., R.C.S., L.L.B., D.A.B., J.A.S.), and Departments of Neurological Sciences (Z.A., A.W.C., M.L., L.L.B., D.A.B., J.A.S.), Family Medicine (R.C.S.), Behavioral Sciences (L.L.B.), and Pathology (J.A.S.), Rush University Medical Center, Chicago, IL.
Anna Needs Neuroblastoma Answers · US

Funding

SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1M
EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
RISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4M
Risk Factors for Cognitive Decline in African-AmericansR01AG022018 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BARNES, LISA L · 2004 to 2025
$18.2M
Racial Differences in Late-Life Cognitive Decline and Risk of Alzheimer's DiseaseRF1AG022018 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BARNES, LISA L · 2016 to 2019
$6.6M
Risk Factors, Pathology, and Clinical Expressions of ADRF1AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2014 to 2014
$6.0M
Multimodal MRI biomarkers of small vessel disease for older persons with and without dementia.UH3NS100599 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI ARFANAKIS, KONSTANTINOS, SCHNEIDER, JULIE A. · 2018 to 2020
$3.5M
Mechanisms linking insulin resistance to brain structure, pathology, and functionR01NS084965 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI AHIMA, REXFORD S., ARNOLD, STEVEN E · 2014 to 2018
$3.2M
Vascular Cognitive and Motor Decline: Impact of aPLR01AG040039 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI ARVANITAKIS, ZOE · 2011 to 2015
$2.9M
Longitudinal validation of cerebral small vessel disease biomarkers in diverse community-based older adults without dementiaUF1NS100599 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI ARFANAKIS, KONSTANTINOS, SCHNEIDER, JULIE A. · 2021 to 2021
$2.5M
Multimodal MRI biomarkers of small vessel disease for older persons with and without dementia.UH2NS100599 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI ARFANAKIS, KONSTANTINOS, SCHNEIDER, JULIE A. · 2016 to 2017
$2.2M
NIA NIH HHS P30 AG010161NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG022018NIA NIH HHS R01 AG040039NIA NIH HHS RF1 AG015819NIA NIH HHS RF1 AG022018NINDS NIH HHS R01 NS084965NINDS NIH HHS UF1 NS100599NINDS NIH HHS UH2 NS100599NINDS NIH HHS UH3 NS100599
6 · The paper itself

Abstract

objectiveTo examine associations of average and change in late-life blood pressure (BP) with cerebrovascular and Alzheimer disease (AD) neuropathology in a large group of decedents followed longitudinally in vivo.

methodsThis clinical-pathologic study was derived from prospective, community-based cohort studies of aging with similar design and data collection. Measurements of systolic BP (SBP) and diastolic BP (DBP) were obtained annually (mean follow-up 8 years, SD = 4.8). Postmortem neuropathologic evaluations documented diseases of aging. Using regression analyses, we examined associations of average and decline in late-life SBP, and separately in DBP, with neuropathology.

resultsIn 1,288 persons (mean age at death = 88.6 years; 65% women), the mean standardized person-specific SBP across the study was 134 (SD = 13) and DBP was 71 (SD = 8) mm Hg. The odds of brain infarcts were increased for participants with a higher mean SBP. Specifically, a person with a 1 SD SBP above the mean (147 vs 134 mm Hg) would have a 46% increased odds of having one or more infarcts, and an increased odds of gross infarct (46%) and microinfarct (36%). Furthermore, a more rapidly declining SBP slope over time increased the odds of one or more infarcts. Mean DBP, not slope, was related to brain infarcts. AD pathology analyses showed an association of a higher mean SBP with higher number of tangles (

conclusionsHigher average late-life SBP and DBP, and independently a faster decline in SBP, are associated with increasing number of brain infarcts, including gross and microinfarcts. We found some evidence for a relation of SBP with AD, specifically tangles. Both average and decline in BP are related to brain disease.

Indexed as

AgedAged, 80 and overAge FactorsAlzheimer DiseaseBlood PressureBrainCerebrovascular DisordersCohort StudiesFemaleFollow-Up StudiesHumansHypertensionMaleProspective StudiesRisk Factors

Identifiers

PMID29997190
PMCPMC6105052
OpenAlexW2873977728

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.