ArticleBMJ (Clinical research ed.)2018
Risks of ovarian, breast, and corpus uteri cancer in women treated with assisted reproductive technology in Great Britain, 1991-2010: data linkage study including 2.2 million person years of observation.
Article in BMJ (Clinical research ed.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Association between ovarian tumors and exposure to assisted reproductive technologies and ovarian stimulation: a systematic review and meta-analysis.Archives of gynecology and obstetrics · 2024Pooled it
- The association between endometriosis and risk of endometrial cancer and breast cancer: a meta-analysis.BMC women's health · 2022Pooled it
- Pooled it
- Thematic analysis of a United Kingdom-wide survey to explore women's perceptions and concerns about assisted reproductive technology.Human fertility (Cambridge, England) · 2026Article
- Breast ultrasound screening in young adult women undergoing infertility treatment at an infertility clinic: a retrospective observational study.Breast cancer (Tokyo, Japan) · 2026Observational
- Assisted Reproductive Technologies (ART) and breast cancer risk: hormonal treatments under the spotlight.Breast cancer research and treatment · 2026Review
- Assisted Reproductive Technology in Breast and Gynecologic Malignancies: Cancer Risk, Fertility Preservation, and Post-Treatment Reproductive Outcomes.Journal of clinical medicine · 2026Review
- PCOS and breast cancer risk: hormonal modulation and epidemiological trends.Reproductive health · 2026Review
- Cancer Incidence in Women After Medically Assisted Reproduction.JAMA network open · 2026Article
- Does ovarian stimulation accelerate the progression of BI-RADS categories? a propensity score matching-based retrospective cohort study.Frontiers in endocrinology · 2026Article
- Pregnancy-associated breast cancer: gestational weight gain impact and nomogram validation.BMC cancer · 2025Article
- Estrogens and breast cancer.Annals of oncology : official journal of the European Society for Medical Oncology · 2025Review
- Conception and Concern: A Review of Breast Cancer Risk in Assisted Reproductive Technology.International journal of biological sciences · 2025Review
- Effect of different endometrial preparation methods on pregnancy outcome of FET in women with a normal menstrual cycle.Journal of family medicine and primary care · 2024Article
- Infertility and risk of postmenopausal breast cancer in the women's health initiative.Breast cancer research and treatment · 2024Article
- Article
- Effects of Infertility Drug Exposure on the Risk of Borderline Ovarian Tumors: A Systematic Review and Meta-Analysis.Biomedicines · 2023Review
- Repeated Rounds of Gonadotropin Stimulation Induce Imbalance in the Antioxidant Machinery and Activation of Pro-Survival Proteins in Mouse Oviducts.International journal of molecular sciences · 2023Article
- Risk of ovarian cancer in women who give birth after assisted reproductive technology (ART)-a registry-based Nordic cohort study with follow-up from first pregnancy.British journal of cancer · 2023Article
- Understanding How Pregnancy Protects Against Ovarian and Endometrial Cancer Development: Fetal Antigens May Be Involved.Endocrinology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveTo investigate the risks of ovarian, breast, and corpus uteri cancer in women who have had assisted reproduction.
designLarge, population based, data linkage cohort study. SETTING AND
participantsAll women who had assisted reproduction in Great Britain, 1991-2010, as recorded by the Human Fertilisation and Embryology Authority (HFEA).
interventionsHFEA fertility records for cohort members were linked to national cancer registrations.
main outcome measuresObserved first diagnosis of ovarian, breast, and corpus uteri cancer in cohort members were compared with age, sex, and period specific expectation. Standardised incidence ratios (SIRs) were calculated by use of age, sex, and period specific national incidence rates.
results255 786 women contributed 2 257 789 person years' follow-up. No significant increased risk of corpus uteri cancer (164 cancers observed
conclusionsNo increased risk of corpus uteri or invasive breast cancer was detected in women who had had assisted reproduction, but increased risks of in situ breast cancer and invasive and borderline ovarian tumours were found in this study. Our results suggest that ovarian tumour risks could be due to patient characteristics, rather than assisted reproduction itself, although both surveillance bias and the effect of treatment are also possibilities. Ongoing monitoring of this population is essential.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.