Evidence map›Paper›PMID 29997041›Full record

ArticleBiochimica et biophysica acta. Bioenergetics2018

Mitochondrial DNA associations with East Asian metabolic syndrome.

Dimitra Chalkia, Yi-Cheng Chang, Olga Derbeneva, Maria Lvova, Ping Wang, Dan Mishmar, Xiaogang Liu, Larry N Singh, Lee-Ming Chuang, Douglas C Wallace

Abstract read
In one paragraph

Article in Biochimica et biophysica acta. Bioenergetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Novel mitochondrial tRNAWorld journal of pediatrics : WJP · 2020
    Article
  12. Article
  13. Peculiarities of the m.3243A>G variant inMolecular genetics and metabolism reports · 2019
    Article
  14. Article
  15. Mitochondrial genetic medicine.Nature genetics · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Dimitra ChalkiaCenter for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States of America.
Yi-Cheng ChangDepartment of Internal Medicine, National Taiwan University Medical College, Taipei, Taiwan; Graduate Institute of Medical Genomics and Proteomics, National Taiwan University Medical College, Taipei, Taiwan; Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan.
Olga DerbenevaCenter for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States of America; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States of America.
Maria LvovaCenter for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States of America.
Ping WangDepartment of Medicine, University of California, Irvine School of Medicine, Irvine, CA 92697, United States of America.
Dan MishmarDepartment of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Xiaogang LiuDouglas C. Wallace Institute for Mitochondrial and Epigenomic Information Sciences, The Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, PR China; Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, PR China.
Larry N SinghCenter for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States of America.
Lee-Ming ChuangDepartment of Internal Medicine, National Taiwan University Medical College, Taipei, Taiwan.
Douglas C WallaceCenter for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, United States of America; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States of America; Douglas C. Wallace Institute for Mitochondrial and Epigenomic Information Sciences, The Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, PR China; Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, PR China. Electronic address: wallaced1@email.chop.edu.
Children's Hospital of Philadelphia · USNational Taiwan University · TWBen-Gurion University of the Negev · ILUniversity of California, Irvine · USXi'an Jiaotong University · CN

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
INSTITUTE FOR CLINICAL AND TRANSLATIONAL SCIENCEUL1RR031985 · NCRR · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M · 2010 to 2011
$7.2M
MITOCHONDRIAL INBORN ERRORS OF METABOLISMR01NS021328 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI WALLACE, DOUGLAS C · 1985 to 2017
$6.5M
The Intellectual and Developmental Disabilities Research Center at CHOP/PennU54HD086984 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI PUTT, MARY E. · 2016 to 2020
$6.3M
Mitochondrial Diabetes & Manganic Porphyrin TreatmentR01DK073691 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI WALLACE, DOUGLAS C · 2006 to 2010
$1.5M
NCATS NIH HHS UL1 TR001414NCRR NIH HHS UL1 RR031985NICHD NIH HHS U54 HD086984NIDDK NIH HHS R01 DK073691NIH HHS DK73691NIH HHS NS021328NIH HHS UL1 RR031985NIH HHS UL1 TR001414NINDS NIH HHS R01 NS021328
6 · The paper itself

Abstract

Mitochondrial dysfunction has repeatedly been reported associated with type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS), as have mitochondrial DNA (mtDNA) tRNA and duplication mutations and mtDNA haplogroup lineages. We identified 19 Taiwanese T2DM and MS pedigrees from Taiwan, with putative matrilineal transmission, one of which harbored the pathogenic mtDNA tRNA

Indexed as

Polymorphism, Single NucleotideAdultAsia, EasternAsian PeopleCase-Control StudiesDiabetes Mellitus, Type 2DNA, MitochondrialFemaleHaplotypesHumansMaleMetabolic SyndromeMiddle AgedMitochondriaPedigreePhenotypeDNA, MitochondrialCybridsDiabetesHaplogroupMitochondriamtDNAObesity

Identifiers

PMID29997041
PMCPMC6530988
OpenAlexW2844324411

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.