Evidence map›Paper›PMID 29996914›Full record

ReviewJournal for immunotherapy of cancer2018

Perspectives in immunotherapy: meeting report from the Immunotherapy Bridge (29-30 November, 2017, Naples, Italy).

Paolo A Ascierto, James Brugarolas, Luigi Buonaguro, Lisa H Butterfield, David Carbone, Bruno Daniele, Robert Ferris, Bernard A Fox, Jérôme Galon, Cesare Gridelli and 9 more

Abstract readReview
In one paragraph

Review in Journal for immunotherapy of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Paolo A AsciertoMelanoma, Cancer Immunotherapy and Development Therapeutics Oncology Unit, Istituto Nazionale Tumori IRCCS Fondazione "G. Pascale, Napoli, Italy. paolo.ascierto@gmail.com.ORCID 0000-0002-8322-475X
James BrugarolasKidney Cancer Program, Department of Internal Medicine, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Luigi BuonaguroMolecular Biology and Viral Oncology Unit, Istituto Nazionale Tumori IRCCS Fondazione "G. Pascale, Napoli, Italy.
Lisa H ButterfieldUPCI Immunologic Monitoring and Cellular Products Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
David CarboneCollege of Medicine, James Thoracic Center, James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, Ohio, USA.
Bruno DanieleDepartment of Oncology, "G. Rummo" Hospital, Benevento, Italy.
Robert FerrisDivision of Head and Neck Surgery, Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Bernard A FoxLaboratory of Molecular and Tumor Immunology, Robert W. Franz Cancer Research Center in the Earle A. Chiles Research Institute at Providence Cancer Center, Portland, Oregon, USA.
Jérôme GalonNational Institute of Health and Medical Research (INSERM), Paris, France.
Cesare GridelliUnit of Medical Oncology, Hospital "San Giuseppe Moscati", Avellino, Italy.
Howard L KaufmanRobert Wood Johnson Medical School Rutgers, The State University of New Jersey, New Brunswick, New Jersey, USA.
Christopher A KlebanoffCenter for Cell Engineering and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Ignacio MeleroImmunology and Immunotherapy Service, Clinica Universidad de Navarra, Pamplona, Navarra, Spain.
Paul NathanMount Vernon Cancer Centre, Northwood, Middlesex, UK.
Chrystal M PaulosDepartment of Microbiology and Immunology Hollings Cancer Center, Medical University of South Carolina (MUSC), Charleston, South Carolina, USA.
Marco RuellaCenter for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ryan SullivanMedicine Harvard Medical School and Haematology/Oncology Department, Massachusetts General Hospital, Boston, Massachusetts, USA.
Hassane ZarourMelanoma Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA.
Igor PuzanovEarly Phase Clinical Trials Program, Experimental Therapeutics Program, Melanoma Section, Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York, USA.

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
Project 3: Combinatorial and gene-editing approaches to enhance the efficacy of CAR T cell therapy of multiple myeloma.P01CA214278 · NCI · UNIVERSITY OF PENNSYLVANIA · PI CARL H. JUNE · 2017 to 2026
$26.8M
Resistance To Targeted Immunotherapies:CART19 as a ParadigmR00CA212302 · NCI · UNIVERSITY OF PENNSYLVANIA · PI RUELLA, MARCO · 2018 to 2020
$608k
Resistance To Targeted Immunotherapies:CART19 as a ParadigmK99CA212302 · NCI · UNIVERSITY OF PENNSYLVANIA · PI RUELLA, MARCO · 2017 to 2018
$348k
NCI NIH HHS K99 CA212302NCI NIH HHS P01 CA214278NCI NIH HHS P30 CA016058NCI NIH HHS R00 CA212302
6 · The paper itself

Abstract

Immunotherapy represents the third important wave in the history of the systemic treatment of cancer after chemotherapy and targeted therapy and is now established as a potent and effective treatment option across several cancer types. The clinical success of anti-cytotoxic T-lymphocyte-associated antigen (CTLA)-4, first, and anti-programmed death (PD)-1/PD-ligand (L)1 agents in melanoma and other cancers a few years later, has encouraged increasing focus on the development of other immunotherapies (e.g. monoclonal antibodies with other immune targets, adoptive cell transfer, and vaccines), with over 3000 immuno-oncology trials ongoing, involving hundreds of research institutes across the globe. The potential use of these different immunotherapeutic options in various combinations with one another and with other treatment modalities is an area of particular promise. The third Immunotherapy Bridge meeting (29-30 November, 2017, Naples, Italy) focused on recent advances in immunotherapy across various cancer types and is summarised in this report.

Indexed as

ImmunotherapyAnimalsAntigen PresentationAntineoplastic Agents, ImmunologicalBiomarkers, TumorCancer VaccinesCTLA-4 AntigenHumansImmunomodulationLiquid BiopsyMutationNeoplasmsProgrammed Cell Death 1 ReceptorT-LymphocytesTranslational Research, BiomedicalTumor MicroenvironmentAntineoplastic Agents, ImmunologicalBiomarkers, TumorCancer VaccinesCTLA-4 AntigenCTLA4 protein, humanProgrammed Cell Death 1 ReceptorAdoptive cell transfer combination therapyBiomarkersCancer vaccinesCheckpoint inhibitorsImmunotherapy

Identifiers

PMID29996914
PMCPMC6042369

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.