ArticleBMC genomics2018
Whole-transcriptome changes in gene expression accompany aging of sensory neurons in Aplysia californica.
Article in BMC genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Diet-Dependent Variations in the Gut Microbiota and Metabolic Pathways of the land slug Deroceras laeve.Microbial ecology · 2026Article
- Transcriptomic differences in immune- and stress-related pathways associated with artificial rearing in the endangered hog deer (Axis porcinus).BMC genomics · 2026Article
- Age-related degradation of behavioral and network features ofFrontiers in aging neuroscience · 2026Article
- Age-related degradation of behavioral and network features ofbioRxiv : the preprint server for biology · 2025Article
- Animal models in neuroscience with alternative approaches: Evolutionary, biomedical, and ethical perspectives.Animal models and experimental medicine · 2024Review
- Host response to Aplysia Abyssovirus 1 in nervous system and gill.Developmental and comparative immunology · 2024Article
- Single-neuron analysis of aging-associated changes in learning reveals impairments in transcriptional plasticity.Aging cell · 2024Article
- Expression dynamics of the aplysia abyssovirus.Virology · 2024Article
- SlugAtlas, a histological and 3D online resource of the land slugs Deroceras laeve and Ambigolimax valentianus.PloS one · 2024Article
- Two distinct evolutionary conserved neural degeneration pathways characterized in a colonial chordate.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Aplysia Neurons as a Model of Alzheimer's Disease: Shared Genes and Differential Expression.Journal of molecular neuroscience : MN · 2022Article
- Transcriptome analysis provides genome annotation and expression profiles in the central nervous system of Lymnaea stagnalis at different ages.BMC genomics · 2021Article
- Co-expression analysis identifies neuro-inflammation as a driver of sensory neuron aging in Aplysia californica.PloS one · 2021Article
- Article
- Changes in Metabolism and Proteostasis Drive Aging Phenotype inFrontiers in aging neuroscience · 2020Article
- Workshop report: Cryopreservation of aquatic biomedical models.Cryobiology · 2019Article
- Altered expression of ionotropic L-Glutamate receptors in aged sensory neurons of Aplysia californica.PloS one · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundLarge-scale molecular changes occur during aging and have many downstream consequences on whole-organism function, such as motor function, learning, and memory. The marine mollusk Aplysia californica can be used to study transcriptional changes that occur with age in identified neurons of the brain, because its simplified nervous system allows for more direct correlations between molecular changes, physiological changes, and their phenotypic outcomes. Behavioral deficits in the tail-withdrawal reflex of aged animals have been correlated with reduced excitation in sensory neurons that control the reflex. RNASeq was used to investigate whole-transcriptome changes in tail-withdrawal sensory neurons of sexually mature and aged Aplysia to correlate transcriptional changes with reduced behavioral and physiological responses.
resultsPaired-end sequencing resulted in 210 million reads used for differential expression analysis. Aging significantly altered expression of 1202 transcripts in sensory neurons underlying the tail-withdrawal reflex, with an approximately equal number of these genes up- and down regulated with age. Despite overall bidirectionality of expression changes, > 80% of ion channel genes that were differentially expressed had decreased expression with age. In particular, several voltage-gated K
conclusionsSignificantly altered expression of many genes between sexually mature and aged Aplysia suggests large molecular changes that may impact neuronal function. Decreased ion channel mRNA observed could mean fewer receptors present in aged neurons, resulting in reduced excitability of PVC sensory neurons, ultimately leading to reduced tail-withdrawal reflex observed in aged Aplysia. Significant changes in other genes and pathways, such as stress response and learning and memory, have previously been shown to occur with age in many vertebrate organisms. This suggests that some effects of aging are common across many animal phyla.
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