Evidence map›Paper›PMID 29996675›Full record

ArticleThe Journal of international medical research2018

Acute allograft rejection in liver transplant recipients: Incidence, risk factors, treatment success, and impact on graft failure.

Nurettin Dogan, Anna Hüsing-Kabar, Hartmut H Schmidt, Vito R Cicinnati, Susanne Beckebaum, Iyad Kabar

Abstract read
In one paragraph

Article in The Journal of international medical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Observational
  13. Incidence of acute rejection and patient survival in combined heart-liver transplantation.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2022
    Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Successful liver transplantation in a patient recovered from COVID-19.Transplant infectious disease : an official journal of the Transplantation Society · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nurettin DoganDepartment of Gastroenterology and Hepatology, University Hospital Muenster, Muenster, Germany.
Anna Hüsing-KabarDepartment of Gastroenterology and Hepatology, University Hospital Muenster, Muenster, Germany.
Hartmut H SchmidtDepartment of Gastroenterology and Hepatology, University Hospital Muenster, Muenster, Germany.
Vito R CicinnatiDepartment of Gastroenterology and Hepatology, University Hospital Muenster, Muenster, Germany.
Susanne BeckebaumDepartment of Gastroenterology and Hepatology, University Hospital Muenster, Muenster, Germany.
Iyad KabarDepartment of Gastroenterology and Hepatology, University Hospital Muenster, Muenster, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective This study was performed to identify risk factors for acute cellular rejection after liver transplantation (LT). Methods Consecutive LT recipients who underwent surgery in our institution from 2002 to 2015 were retrospectively evaluated. Results In total, 176 patients were eligible for statistical analysis. During a mean observation period of 61.1 ± 36.3 months, 43 episodes of acute rejection were evident. Of these, 34 (79.0%) were responsive to methylprednisolone, 3 (7.0%) were treated by adjusting the dosage of immunosuppressive agents, and 6 (14.0%) were methylprednisolone-resistant and treated using anti-thymocyte globulin. Biliary complications (odds ratio [OR] = 4.89, 95% confidence interval [CI] = 2.00-11.98); donor-negative, recipient-positive CMV mismatch (OR = 9.88, 95% CI = 1.18-82.36); sex mismatch (OR = 3.16, 95% CI = 1.31-8.10); and sex mismatch with a female donor (OR = 3.00, 95% CI = 1.10-7.58) were identified as significant risk factors for acute graft rejection after LT. Conclusion In patients who develop acute cellular rejection after LT, biliary complications should be evaluated as a potential cause. Most acute rejections after LT respond to bolus corticosteroid therapy.

Indexed as

Graft SurvivalAdultAgedAllograftsAntilymphocyte SerumBile Duct DiseasesFemaleGlucocorticoidsGraft RejectionHumansImmunosuppressive AgentsIncidenceLiver TransplantationMaleMethylprednisoloneMiddle AgedAntilymphocyte SerumGlucocorticoidsImmunosuppressive AgentsMethylprednisoloneacute cellular rejectionbiliary complicationscorticosteroidscytomegalovirus mismatchLiver transplantationsex mismatch

Identifiers

PMID29996675
PMCPMC6136012

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.