Evidence map›Paper›PMID 29996549›Full record

ArticleAntioxidants (Basel, Switzerland)2018

Proteomics and Toxicity Analysis of Spinal-Cord Primary Cultures upon Hydrogen Sulfide Treatment.

Viviana Greco, Alida Spalloni, Victor Corasolla Carregari, Luisa Pieroni, Silvia Persichilli, Nicola B Mercuri, Andrea Urbani, Patrizia Longone

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Hydrogen Sulfide Signaling in Neurodegenerative Movement Disorders.Handbook of experimental pharmacology · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Advances of HAntioxidants (Basel, Switzerland) · 2023
    Review
  10. Comparative proteomics ofOne health (Amsterdam, Netherlands) · 2021
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Viviana GrecoInstitute of Biochemistry and Clinical Biochemistry, Università Cattolica del Sacro Cuore, 00168 Rome, Italy. vivianagreco82@yahoo.it.
Alida SpalloniDepartment of Experimental Neuroscience, Molecular Neurobiology Unit, Fondazione Santa Lucia, 00143 Rome, Italy. a.spalloni@hsantalucia.it.
Victor Corasolla CarregariInstitute of Biochemistry and Clinical Biochemistry, Università Cattolica del Sacro Cuore, 00168 Rome, Italy. corasolla@gmail.com.
Luisa PieroniDepartment of Experimental Neuroscience, Proteomics and Metabonomics Unit, Fondazione Santa Lucia-IRCCS, 00143 Rome, Italy. l.pieroni@hsantalucia.it.
Silvia PersichilliInstitute of Biochemistry and Clinical Biochemistry, Università Cattolica del Sacro Cuore, 00168 Rome, Italy. silvia.persichilli@unicatt.it.
Nicola B MercuriDepartment of Systems Medicine, Policlinico Universitario "Tor Vergata", University of Rome "Tor Vergata", 00133 Rome, Italy. mercurin@med.uniroma2.it.
Andrea UrbaniInstitute of Biochemistry and Clinical Biochemistry, Università Cattolica del Sacro Cuore, 00168 Rome, Italy. andrea.urbani@unicatt.it.
Patrizia LongoneDepartment of Experimental Neuroscience, Molecular Neurobiology Unit, Fondazione Santa Lucia, 00143 Rome, Italy. p.longone@hsantalucia.it.
Università Cattolica del Sacro Cuore · ITFondazione Santa Lucia · ITUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydrogen sulfide (H₂S) is an endogenous gasotransmitter recognized as an essential body product with a dual, biphasic action. It can function as an antioxidant and a cytoprotective, but also as a poison with a high probability of causing brain damage when present at noxious levels. In a previous study, we measured toxic liquoral levels of H₂S in sporadic amyotrophic lateral sclerosis (ALS) patients and in the familial ALS (fALS) mouse model, SOD1G93A. In addition, we experimentally demonstrated that H₂S is extremely and selectively toxic to motor neurons, and that it is released by glial cells and increases Ca

Indexed as

apoptosishydrogen sulfidemotor neuronnecroptosisproteomics

Identifiers

PMID29996549
PMCPMC6070951
OpenAlexW2868459966

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.