Evidence map›Paper›PMID 29996472›Full record

ArticleInternational journal of molecular sciences2018

ERK5 Phosphorylates K

Yurina Kashino, Yutaro Obara, Yosuke Okamoto, Takeo Saneyoshi, Yasunori Hayashi, Kuniaki Ishii

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Preferential Expression of CaBiomolecules · 2022
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yurina KashinoDepartment of Pharmacology, Yamagata University School of Medicine, Yamagata 990-9585, Japan. yurikamo_chronicle@yahoo.co.jp.
Yutaro ObaraDepartment of Pharmacology, Yamagata University School of Medicine, Yamagata 990-9585, Japan. okamoto@med.akita-u.ac.jp.
Yosuke OkamotoDepartment of Pharmacology, Yamagata University School of Medicine, Yamagata 990-9585, Japan. okamoto@med.akita-u.ac.jp.
Takeo SaneyoshiDepartment of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan. saneyoshi.takeo.3v@kyoto-u.ac.jp.
Yasunori HayashiDepartment of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan. yhayashi-tky@umin.ac.jp.ORCID 0000-0002-7560-3004
Kuniaki IshiiDepartment of Pharmacology, Yamagata University School of Medicine, Yamagata 990-9585, Japan. kuishii@med.id.yamagata-u.ac.jp.
Yamagata University · JPKyoto University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular signal-regulated kinase 5 (ERK5) regulates diverse physiological responses such as proliferation, differentiation, and gene expression. Previously, we demonstrated that ERK5 is essential for neurite outgrowth and catecholamine biosynthesis in PC12 cells and sympathetic neurons. However, it remains unclear how ERK5 regulates the activity of ion channels, which are important for membrane excitability. Thus, we examined the effect of ERK5 on the ion channel activity in the PC12 cells that overexpress both ERK5 and the constitutively active MEK5 mutant. The gene and protein expression levels of voltage-dependent Ca

Indexed as

AnimalsCatecholaminesCell DifferentiationGene Expression RegulationMembrane PotentialsMitogen-Activated Protein Kinase 7NeuronsPatch-Clamp TechniquesPC12 CellsPhosphorylationRatsShal Potassium ChannelsSignal TransductionCatecholaminesKcnd2 protein, ratMitogen-Activated Protein Kinase 7Shal Potassium Channelsextracellular signal-regulated kinase 5 (ERK5)Kv4.2PC12 cells

Identifiers

PMID29996472
PMCPMC6073465
OpenAlexW2833457594

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.