Evidence map›Paper›PMID 29996103›Full record

ArticleCell reports2018

NAD

David Pajuelo, Norberto Gonzalez-Juarbe, Uday Tak, Jim Sun, Carlos J Orihuela, Michael Niederweis

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 187 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. ThemBio · 2026
    Article
  7. Differential survival and tolerance mechanisms ofApplied and environmental microbiology · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Protein Architecture and Composition in Mycobacterium tuberculosis.Advances in experimental medicine and biology · 2026
    Review
  12. Protein-Mediated Virulence in Mycobacterium tuberculosis.Advances in experimental medicine and biology · 2026
    Review
  13. Article
  14. A metabolic cell death program downstream of SARM1 couples NADProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. Review
  16. Article
  17. Article
  18. Cell death pathways in response toInfection and immunity · 2025
    Review
  19. bioRxiv : the preprint server for biology · 2025
    Article
  20. Article

61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

David PajueloDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Norberto Gonzalez-JuarbeDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Uday TakDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Jim SunDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Carlos J OrihuelaDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Michael NiederweisDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: mnieder@uab.edu.
University of Alabama at Birmingham · US

Funding

IMMUNOLOGIC DISEASES AND BASIC IMMUNOLOGYT32AI007051 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Laurie Ellen Harrington · 1985 to 2026
$13.1M
Cardiac microlesion formation during invasive pneumococcal diseaseR01AI114800 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Carlos J Orihuela, Herve S TETTELIN · 2015 to 2026
$5.1M
The necrosis-inducing toxin of Mycobacterium tuberculosisR01AI121354 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI NIEDERWEIS, MICHAEL · 2016 to 2020
$2.5M
Inhibition of necroptosis during inflamm-aging and pneumoniaR21AG055144 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ORIHUELA, CARLOS J · 2016 to 2017
$404k
NIAID NIH HHS R01 AI114800NIAID NIH HHS R01 AI121354NIAID NIH HHS T32 AI007051NIA NIH HHS R21 AG055144
6 · The paper itself

Abstract

Mycobacterium tuberculosis (Mtb) kills infected macrophages by inhibiting apoptosis and promoting necrosis. The tuberculosis necrotizing toxin (TNT) is a secreted nicotinamide adenine dinucleotide (NAD

Indexed as

ApoptosisAnimalsBacterial ToxinsBiocatalysisCytoprotectionHumansJurkat CellsMacrophagesMice, Inbred C57BLMitochondriaModels, BiologicalMycobacterium tuberculosisNADNAD+ NucleosidaseNecrosisNiacinamideBacterial ToxinsMLKL protein, humanNADNAD+ NucleosidaseNiacinamideProtein KinasesReceptor-Interacting Protein Serine-Threonine KinasesRIPK1 protein, humanRIPK3 protein, humanTumor Necrosis Factor-alphacell deathmitochondriaMLKLNAD(+)necroptosisRIPK3TNTtoxintuberculosis

Identifiers

PMID29996103
PMCPMC6136256
OpenAlexW2827348114

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.