ArticleMolecular microbiology2018
A cluster of residues in the lipopolysaccharide exporter that selects substrate variants for transport to the outer membrane.
Article in Molecular microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Inhibiting Lipopolysaccharide Biogenesis: The More You Know the Further You Go.Annual review of biochemistry · 2025Review
- Structural Insights into the Lipopolysaccharide Transport (Lpt) System as a Novel Antibiotic Target.Journal of microbiology (Seoul, Korea) · 2024Review
- ABC Transporters in Bacterial Nanomachineries.International journal of molecular sciences · 2023Review
- Genome-Wide Analysis of Innate Susceptibility Mechanisms ofAntibiotics (Basel, Switzerland) · 2022Article
- The transmembrane α-helix of LptC participates in LPS extraction by the LptBMolecular microbiology · 2022Article
- Assembly and Maintenance of Lipids at the Bacterial Outer Membrane.Chemical reviews · 2021Review
- Transport of lipopolysaccharides and phospholipids to the outer membrane.Current opinion in microbiology · 2021Review
- A Single Nucleotide Polymorphism inFrontiers in microbiology · 2021Article
- Lipopolysaccharide transport involves long-range coupling between cytoplasmic and periplasmic domains of the LptBJournal of bacteriology · 2020Article
- High-resolution views of lipopolysaccharide translocation driven by ABC transporters MsbA and LptBCurrent opinion in structural biology · 2020Review
- LptB-LptF coupling mediates the closure of the substrate-binding cavity in the LptBMolecular microbiology · 2020Article
- Cryo-EM structures of lipopolysaccharide transporter LptBNature communications · 2019Article
- Pushing the envelope: LPS modifications and their consequences.Nature reviews. Microbiology · 2019Review
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Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Most Gram-negative bacteria assemble lipopolysaccharides (LPS) on their surface to form a permeability barrier against many antimicrobials. LPS is synthesized at the inner membrane and then transported to the outer leaflet of the outer membrane. Although the overall LPS structure is conserved, LPS molecules can differ in composition at the species and strain level. Some bacteria also regulate when to modify phosphates on LPS at the inner membrane in order to become resistant to cationic antimicrobial peptides. The multi-protein Lpt trans-envelope machine, which transports LPS from the inner to the outer membrane, must therefore handle a variety of substrates. The most poorly understood step in LPS transport is how the ATP-binding cassette LptB
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.