ArticleNature2018
Reprogramming human T cell function and specificity with non-viral genome targeting.
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In one paragraph
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 514 papers.
0numbers the graph read from it
0cells of the map it votes in
514citing papers in PubMed
35.5field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
514 citing papers in PubMed, 825 citations in OpenAlex.
- Chromatin Modifications Orchestrate DNA Repair Pathway Choice: Epigenetics Strategies for Enhancing CRISPR-Cas9-Mediated Knock-In Efficiency.Cell proliferation · 2026Review
- Strategies and mechanisms of precision genome engineering: From gene editing to genome writing.iMetaOmics · 2026Review
- Cell-based cancer immunotherapy: milestones, mechanistic insights, and emerging therapeutic directions.Acta pharmacologica Sinica · 2026Review
- Article
- Precise genomic integration of large DNA fragments by donor-directed annealing using prime editing.Nature biotechnology · 2026Article
- From Delivery to Design: Site-Specific Genome Engineering for Next-Generation CAR T-Cell Therapy.Biomedicines · 2026Review
- Review
- Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells.Nature biotechnology · 2026Article
- Biomaterial-Integrated Electroporation for Therapeutic Delivery: From Gene Editing to Tumor Ablation and Immune Modulation.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- A modular γδ TCR-T platform combining KRAS pMHC targeting with re-dosable mRNA engager redirection.Journal of hematology & oncology · 2026Article
- Mechanisms, optimization strategies, and salvage options for CAR-T cell therapy.Biomarker research · 2026Review
- CRISPR-Cas9: Genome Engineering and Future Vaccine Applications.Molecular biotechnology · 2026Review
- The T Cell Receptor: Molecular Sensor, Therapeutic Mediator and Probabilistic Driver of Adaptive Immunity.Immunological reviews · 2026Review
- Retargeted serine integrases for one-step, precise integration of large DNA sequences in human cells.Nature biotechnology · 2026Article
- Engineering Strategies for Allogeneic T Cell-Based Platforms in Cancer Immunotherapy.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Engineering T cells with a novel PD-L1-specific TCR targeting immune and cancer cells.Signal transduction and targeted therapy · 2026Article
- Non-viral targeted integration at the CISH locus enables CAR-NK cell engineering with enhanced anti-tumor activity.Molecular therapy. Oncology · 2026Article
- Next-generation CAR-NK cell therapy: engineering strategies, translational challenges, and future perspectives in cancer immunotherapy.Cancer cell international · 2026Review
- Dual CD8 and TCR editing in regulatory T cells mediates HLA-A2-restricted tissue-specific homing.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Selection of human hematopoietic stem cells bearing the intended functional edit by transient AND-gate reporters.Nature biotechnology · 2026Article
454 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
45 authors at 16 institutions in 1 country.
Theodore L RothMedical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA.
Cristina Puig-SausDepartment of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Ruby YuDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.
Eric ShifrutDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.
Julia CarnevaleUCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.
P Jonathan LiDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.
Joseph HiattMedical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA.
Justin SacoDepartment of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Paige KrystofinskiDepartment of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Han LiDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.
Victoria TobinDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.
David N NguyenDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.
Michael R LeeDiabetes Center, University of California, San Francisco, San Francisco, CA, USA.
Amy L PutnamDiabetes Center, University of California, San Francisco, San Francisco, CA, USA.
Andrea L FerrisHIV Dynamics and Replication Program, Vector Design and Replication Section, National Cancer Institute, Frederick, MD, USA.
Jeff W ChenDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Jean-Nicolas SchickelDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Laurence PellerinDivision of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.
David CarmodySection of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, Departments of Medicine and Pediatrics, The University of Chicago, Chicago, IL, USA.
Gorka Alkorta-AranburuDepartment of Human Genetics, The University of Chicago, Chicago, IL, USA.
Daniela Del GaudioDepartment of Human Genetics, The University of Chicago, Chicago, IL, USA.
Hiroyuki MatsumotoTakara Bio USA, Inc, Mountain View, CA, USA.
Montse MorellTakara Bio USA, Inc, Mountain View, CA, USA.
Ying MaoTakara Bio USA, Inc, Mountain View, CA, USA.
Min ChoChan Zuckerberg Biohub, San Francisco, CA, USA.
Rolen M QuadrosMouse Genome Engineering Core Facility, Vice Chancellor for Research Office, University of Nebraska Medical Center, Omaha, NE, USA.
Channabasavaiah B GurumurthyMouse Genome Engineering Core Facility, Vice Chancellor for Research Office, University of Nebraska Medical Center, Omaha, NE, USA.
Baz SmithTakara Bio USA, Inc, Mountain View, CA, USA.
Michael HaugwitzTakara Bio USA, Inc, Mountain View, CA, USA.
Stephen H HughesHIV Dynamics and Replication Program, Vector Design and Replication Section, National Cancer Institute, Frederick, MD, USA.
Jonathan S WeissmanDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.
Kathrin SchumannDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.
Jonathan H EsenstenDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
Andrew P MayChan Zuckerberg Biohub, San Francisco, CA, USA.
Alan AshworthUCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.
Gary M KupferDepartment of Pediatrics, Pathology, Yale School of Medicine, New Haven, CT, USA.
Siri Atma W GreeleySection of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, Departments of Medicine and Pediatrics, The University of Chicago, Chicago, IL, USA.
Rosa BacchettaDivision of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.
Eric MeffreDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Maria Grazia RoncaroloDivision of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.
Neil RombergDivision of Immunology and Allergy, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Kevan C HeroldDepartments of Immunobiology and Internal Medicine, Yale University, New Haven, CT, USA.
Antoni RibasDepartment of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Manuel D LeonettiDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.
Alexander MarsonDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA. alexander.marson@ucsf.edu.
University of California, San Francisco · USYale University · USTakara (United States) · USInnovative Genomics Institute · USUniversity of Chicago · USHoward Hughes Medical Institute · USUniversity of California, Los Angeles · USCalifornia Institute for Regenerative Medicine · USChan Zuckerberg Initiative (United States) · USUCSF Helen Diller Family Comprehensive Cancer Center · USUniversity of Nebraska Medical Center · USNational Cancer Institute · USStanford University · USUniversity of California, Berkeley · USUniversity of Colorado Cancer Center · USUniversity of Pennsylvania · US
Funding
Translational InformaticsP30CA082103 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer Leigh Clarke · 1999 to 2026
$209.7MX-ray Screening and Rapid Structure DeterminationP50GM082250 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FRANKEL, ALAN D · 2007 to 2018
$48.8MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6MResearch BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRUMMEL, MATTHEW F · 2003 to 2019
$21.8MPilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI Matthew J Brady · 2013 to 2026
$20.9MDIABETES, ENDOCRINOLOGY &METABOLISM TRAINING PROGRAMT32DK007418 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EDWARD C HSIAO · 1986 to 2026
$14.3MIntegraseZIABC011426 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI HUGHES, STEPHEN H · 2012 to 2022
$14.0MMOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0MMolecular and Cellular Mechanisms in CancerT32CA108462 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOGA, ANDREI · 2004 to 2024
$10.4MNext Generation Cancer Immunotherapies to Defeat MelanomaR35CA197633 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANTONI RIBAS · 2015 to 2026
$10.4MBIOLOGY OF INFECTIOUS DISEASES TRAINING PROGRAMT32AI007641 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHEW G DORSEY · 2000 to 2026
$6.9MFunctional Interrogation of Non-Coding Type 1 Diabetes Risk Variants in Human Immune Cells and Beta CellsDP3DK111914 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARSON, ALEXANDER · 2016 to 2016
$3.7MNCI NIH HHS P30 CA082103NCI NIH HHS R35 CA197633NCI NIH HHS T32 CA108462NIAID NIH HHS K23 AI115001NIAID NIH HHS L40 AI140341NIAID NIH HHS T32 AI007334NIAID NIH HHS T32 AI007641NIDDK NIH HHS DP3 DK111914NIDDK NIH HHS K23 DK094866NIDDK NIH HHS P30 DK020595NIDDK NIH HHS P30 DK063720NIDDK NIH HHS T32 DK007418NIGMS NIH HHS P50 GM082250NIGMS NIH HHS T32 GM007618NIH HHS S10 OD021822
Abstract
Decades of work have aimed to genetically reprogram T cells for therapeutic purposes
Indexed as
Gene EditingAnimalsAutoimmunityCells, CulturedCellular ReprogrammingCRISPR-Cas SystemsGenome, HumanHumansInterleukin-2 Receptor alpha SubunitMaleMiceNeoplasm TransplantationProtein EngineeringReceptors, Antigen, T-CellT-LymphocytesIL2RA protein, humanInterleukin-2 Receptor alpha SubunitReceptors, Antigen, T-Cell
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.