ArticleNature2018
Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.
0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed
17.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
118 citing papers in PubMed, 256 citations in OpenAlex.
- Coordinating structure-guided design and cis-regulatory optimization to engineer elite herbicide-tolerance alleles in crops.Nature plants · 2026Article
- Synthesis, Herbicidal Activity Evaluation, and Molecular Docking of Novel Acylthioureas as AHAS Inhibitors.Molecules (Basel, Switzerland) · 2026Article
- Targeted identification of new phaterpenes and elucidation of the relevant biosynthetic pathway inSynthetic and systems biotechnology · 2026Article
- Self-Resistance as a Functional Beacon: Target-Directed Microbial Genome Mining from Classical Discovery to Automated Pipelines.Microorganisms · 2026Review
- Self-resistance as a guide to discovering bioactive natural products.Current opinion in chemical biology · 2026Review
- Anchoring mechanism-inspired discovery of a bacterial P450 gene conferring resistance to auxin herbicides.Nature communications · 2026Article
- Resistance-CONKAT-seq Guided Discovery of a ClpP Active Natural Product from a Soil Metagenome.ACS chemical biology · 2026Article
- Mode of action guided metagenomic natural product discovery reveals convergent evolution of a ClpP-targeting motif.Nature communications · 2026Article
- An Antifungal with a Novel Mechanism of Action Discovered via Resistance Gene-Guided Genome Mining.ACS central science · 2026Article
- A Bifunctional Cytochrome P450 Enzyme Catalyzes Hydroxylation and Aryl-Aryl Ether Formation in the Biosynthesis of Emestrin.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- De Novo Design and Synthesis of Novel Benzoxazinone Derivatives Targeting Dihydroxyacid Dehydratase.Plant biotechnology journal · 2026Article
- A synbiotic approach to the formulation of innovative bioherbicides for weed control: a global perspective.Frontiers in plant science · 2026Article
- Design, Synthesis, Anti-Oomycete, and Insecticidal Activities of 3β-Acyloxy-18β-Glycyrrhetinic Acid Derivatives.Chemistry & biodiversity · 2026Article
- Sesquiterpene synthases fromMycology · 2026Article
- Resistance Gene-Guided Discovery of a Fungal Spirotetramate as an Acetolactate Synthase Inhibitor.Journal of the American Chemical Society · 2025Article
- Biosynthesis of the 5-Isoxazolidinone-Containing Hexacyclic Structure of Parnafungin.Journal of the American Chemical Society · 2025Article
- Discovery of UbiA-Type Cyathane Synthases in Bacteria.ACS catalysis · 2025Article
- The herbicidal natural product phosphonothrixin is an inhibitor of the riboflavin biosynthetic enzyme L-3,4-dihydroxy-2-butanone-4-phosphate synthase.Pest management science · 2025Article
- Resistance Gene-Guided Genome Mining Reveals RPL10 as the Target of Ligustrone A.Journal of the American Chemical Society · 2025Article
- Substrate-based discovery of α-hydroxycarboxylic acid derivatives as potential herbicides targeting dihydroxyacid dehydratase.Nature communications · 2025Article
58 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Yan YanDepartment of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA, USA.
Qikun LiuDepartment of Molecular, Cell, and Developmental Biology and Howard Hughes Medical Institute, University of California Los Angeles, Los Angeles, CA, USA.
Xin ZangState Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
Shuguang YuanLaboratory of Physical Chemistry of Polymers and Membranes, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Undramaa Bat-ErdeneDepartment of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA, USA.
Calvin NguyenDepartment of Molecular, Cell, and Developmental Biology and Howard Hughes Medical Institute, University of California Los Angeles, Los Angeles, CA, USA.
Jianhua GanState Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai, China.
Jiahai ZhouState Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China. jiahai@mail.sioc.ac.cn.
Steven E JacobsenDepartment of Molecular, Cell, and Developmental Biology and Howard Hughes Medical Institute, University of California Los Angeles, Los Angeles, CA, USA. jacobsen@ucla.edu.
Yi TangDepartment of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA, USA. yitang@ucla.edu.
University of California, Los Angeles · USChinese Academy of Sciences · CNÉcole Polytechnique Fédérale de Lausanne · CHShanghai Normal University · CNState Key Laboratory of Genetic Engineering
Funding
MIRA: Enzymology and Self-Resistance of Natural Product BiosynthesisR35GM118056 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yi Tang · 2016 to 2026
$6.1MRediscovering Natural Chemical Diversity -1DP1GM106413DP1GM106413 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TANG, YI · 2012 to 2016
$3.9MHoward Hughes Medical InstituteNIGMS NIH HHS DP1 GM106413NIGMS NIH HHS R35 GM118056
Abstract
Bioactive natural products have evolved to inhibit specific cellular targets and have served as lead molecules for health and agricultural applications for the past century
Indexed as
ArabidopsisBiological ProductsEnzyme InhibitorsHerbicide ResistanceHerbicidesHeterocyclic Compounds, 3-RingHydro-LyasesModels, MolecularMultigene FamilyPlant Growth RegulatorsPlants, Genetically ModifiedTransgenesaspterric acidBiological Productsdihydroxyacid dehydrataseEnzyme InhibitorsHerbicidesHeterocyclic Compounds, 3-RingHydro-LyasesPlant Growth Regulators
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.