Evidence map›Paper›PMID 29995849›Full record

ArticleNature2018

Prespliceosome structure provides insights into spliceosome assembly and regulation.

Clemens Plaschka, Pei-Chun Lin, Clément Charenton, Kiyoshi Nagai

Open access · greenAbstract read
In one paragraph

Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 174 citations in OpenAlex.

  1. Article
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  3. Article
  4. Review
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  6. Article
  7. Article
  8. Observational
  9. Article
  10. Article
  11. Article
  12. Control of gene output by intron RNA structure.bioRxiv : the preprint server for biology · 2025
    Article
  13. Epitranscriptomic sculpting: the role of mMedical oncology (Northwood, London, England) · 2025
    Review
  14. Systematic analysis of snRNA genes reveals frequentmedRxiv : the preprint server for health sciences · 2025
    Article
  15. RNA-binding proteins orchestrating immunity in plants.The Plant journal : for cell and molecular biology · 2025
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Clemens PlaschkaMRC Laboratory of Molecular Biology, Cambridge, UK. clemens.plaschka@imp.ac.at.
Pei-Chun LinMRC Laboratory of Molecular Biology, Cambridge, UK. pclin@mrc-lmb.cam.ac.uk.
Clément CharentonMRC Laboratory of Molecular Biology, Cambridge, UK.
Kiyoshi NagaiMRC Laboratory of Molecular Biology, Cambridge, UK. kn@mrc-lmb.cam.ac.uk.
MRC Laboratory of Molecular Biology · GB

Funding

European Research Council 693087Medical Research Council MC_U105184330
6 · The paper itself

Abstract

The spliceosome catalyses the excision of introns from pre-mRNA in two steps, branching and exon ligation, and is assembled from five small nuclear ribonucleoprotein particles (snRNPs; U1, U2, U4, U5, U6) and numerous non-snRNP factors

Indexed as

Cryoelectron MicroscopyAlternative SplicingModels, MolecularRibonucleoproteins, Small NuclearRibonucleoprotein, U1 Small NuclearRibonucleoprotein, U2 Small NuclearRibonucleoprotein, U4-U6 Small NuclearRNA Splice SitesRNA Splicing FactorsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSpliceosomesLuc7 protein, S cerevisiaeNAM8 protein, S cerevisiaeRibonucleoproteins, Small NuclearRibonucleoprotein, U1 Small NuclearRibonucleoprotein, U2 Small NuclearRibonucleoprotein, U4-U6 Small NuclearRNA Splice SitesRNA Splicing FactorsSaccharomyces cerevisiae Proteins

Identifiers

PMID29995849
PMCPMC6141012
OpenAlexW2846099848

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.