SynthesisMedicine2018
A meta-analysis of emotional disorders as possible risk factors for chronic periodontitis.
Synthesis in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The Influence of Psychological Stress and Stress-Related Disorders in the Treatment Outcome of Periodontitis: A Systematic Review and Meta-Analysis.Journal of clinical periodontology · 2025Pooled it
- The association of periodontal diseases and Sjogren's syndrome: A systematic review and meta-analysis.Frontiers in medicine · 2022Pooled it
- Is There Any Association Between Chronic Periodontitis and Anxiety in Adults? A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- Psychological Assessment of Patients With Apical Periodontitis and Caries: A Case-Control Study.International endodontic journal · 2026Observational
- Evaluation of Osteoprotegerin (OPG) and Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL) Biomarker Concentrations in the Saliva of Patients with Periodontitis and Depression.Clinical and experimental dental research · 2026Article
- Reduced prevalence of periodontitis in antidepressant users: Findings from a large-scale US sample.Journal of periodontology · 2026Article
- Mediation of Systemic Inflammation and Oxidative Stress Markers in the Association of Life's Crucial 9 with Periodontitis: Evidence from NHANES 2009-2014.Oral health & preventive dentistry · 2026Article
- Evidence for the association between psychological stress and peri-implant health among middle-aged and elderly adults: A systemic review.World journal of clinical cases · 2025Article
- Serum lipids, oxidative stress, and systemic inflammation mediate the association between circadian syndrome and periodontitis.Frontiers in nutrition · 2025Article
- Evaluation of the Effect of Escitalopram on Alveolar Bone Levels and Periodontal Parameters: A Case-Control Study.International journal of dentistry · 2025Article
- Experimental Periodontitis Increases Anxious Behavior and Worsens Cognitive Aspects and Systemic Oxidative Stress in Wistar Rats.Clinical and experimental dental research · 2024Article
- Periodontal-Systemic Disease: A Study on Medical Practitioners' Knowledge and Practice.International dental journal · 2023Article
- Psychological risk indicators for peri-implantitis: A cross-sectional study.Journal of clinical periodontology · 2022Article
- Psychopathologies and socioeconomic status as risk indicators for periodontitis: a survey-based investigation in German dental practices.Clinical oral investigations · 2022Article
- No bidirectional relationship between depression and periodontitis: A genetic correlation and Mendelian randomization study.Frontiers in immunology · 2022Article
- The Role of the Oral Microbiota Related to Periodontal Diseases in Anxiety, Mood and Trauma- and Stress-Related Disorders.Frontiers in psychiatry · 2021Review
- Oral Colonization byFrontiers in cellular and infection microbiology · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present meta-analysis was to evaluate scientific evidence on the association between emotional disorder (depression and anxiety) and chronic periodontitis. An overall electronic literature search in PubMed, ISI Web of Science, Cochrane Library, and China National Knowledge Infrastructure was undertaken up to November 2017. Newcastle-Ottawa scale was applied to ascertain the validity of each eligible study. Stata statistical software was used to perform meta-analysis. The strength of the association between periodontitis and emotional disorder was measured by odds ratios (ORs) with their 95% confidence intervals (95% CIs). Subgroup analysis and sensitivity analysis were performed. Publication bias was assessed through funnel plots and Begger's test. A total of 14 eligible articles were included in the meta-analysis, 6 of them were focused exclusively on depression, whereas 8 studies investigated both depression and anxiety. There was significant association between emotional disorder and chronic periodontitis (OR = 1.54, 95% CI = 1.27-1.86). Sensitivity analyses confirmed the stability of the present results. No evidence of asymmetry was observed in Begger's test. This meta-analysis demonstrates significant association between emotional disorder (including anxiety and depression) and chronic periodontitis. Nevertheless, the result should be interpreted with caution because of the potential bias and confounding in the included studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.