SynthesisMedicine2018
Migraine as a risk factor for primary open angle glaucoma: A systematic review and meta-analysis.
Synthesis in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Migraine and the risk of glaucoma: a systematic review and meta-analysis.Frontiers in neurology · 2026Pooled it
- Ocular and Systemic Risk Factors and Biomarkers for Primary Glaucoma: An Umbrella Review of Systematic Reviews With Meta-Analyses.Investigative ophthalmology & visual science · 2025Pooled it
- Global incidence and risk factors for glaucoma: A systematic review and meta-analysis of prospective studies.Journal of global health · 2024Pooled it
- Eye disease and mortality, cognition, disease, and modifiable risk factors: an umbrella review of meta-analyses of observational studies.Eye (London, England) · 2022Pooled it
- Retinal oxygen saturation and retinal vessel diameter in glaucoma patients before and after trabeculectomy.Acta ophthalmologica · 2026Article
- Intrinsic Capacity, Polygenic Risk Score, and Risk of Glaucoma.Translational vision science & technology · 2026Article
- Sociodemographic and Clinical Determinants of Glaucoma in a Sub-Saharan African Population: A Case-Control Study.Health science reports · 2026Article
- Current perspectives in tackling glaucoma blindness.Indian journal of ophthalmology · 2025Review
- Eccentricity Dependency of Retinal Electrophysiological Deficits in People With Episodic Migraine.Investigative ophthalmology & visual science · 2024Article
- Postmortem Analysis of Optic Nerve Head Vascularization in an Individual With Glaucoma.Cureus · 2024Article
- Pharmaceutical Approaches to Normal Tension Glaucoma.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Retinal microvasculature features in patients with migraine: a systematic review and meta-analysis.Frontiers in neurology · 2023Review
- Article
- Impact of Systemic Comorbidities on Ocular Hypertension and Open-Angle Glaucoma, in a Population from Spain and Portugal.Journal of clinical medicine · 2022Article
- Longitudinal In Vivo Changes in Radial Peripapillary Capillaries and Optic Nerve Head Structure in Non-Human Primates With Early Experimental Glaucoma.Investigative ophthalmology & visual science · 2022Article
- Arterial hemodynamics and its correlation with retinal microarchitecture in pseudoexfoliation glaucoma.Arquivos brasileiros de oftalmologia · 2022Article
- Predictors of Early Onset Glaucoma.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Glaucoma and optical coherence tomography changes in migraine: A comparative cross-sectional study.Indian journal of ophthalmology · 2021Article
- Air Pollutant Particles, PMInternational journal of environmental research and public health · 2021Article
- Migraine and Medical Ramifications: A Comprehensive Overview Based on Observational Study Meta-Analyses.Frontiers in neurology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Migraine is increasingly being reported as a risk factor for primary open angle glaucoma (POAG). However, studies aimed to investigate this association yielded conflicting results. To assess the consistency of the data on the topic, we performed a systematic review and meta-analysis. A systematic literature search from Embase, Web of Science, and PubMed was performed to identify relevant studies on the relationship between migraine and POAG. Random effects models were used to estimate the pooled relative risks (RRs) with 95% confidence intervals (95% CIs) in this meta-analysis. A total of 11 studies meeting the inclusion criteria were included in this meta-analysis. Our findings showed an RR of developing POAG of 1.24 (95% CI = 1.12-1.37) in migraine patients. No evidence of significant heterogeneity was detected across studies (P = .071; I = 41.7%). This association was not modified by the glaucoma type of the included patients. A significant association was observed in case-control design studies, but not in cohort design studies. Little evidence of publication bias was found. The findings of this meta-analysis suggest that migraine can significantly increase the risk of the development of POAG. However, the cohort study design failed to identify this association. Whether migraines can significantly increase the risk of developing POAG is still controversial.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.