Evidence map›Paper›PMID 29995743›Full record

Trial reportObstetrics and gynecology2018

Institutional Protocols for Vaginal Preparation With Antiseptic Solution and Surgical Site Infection Rate in Women Undergoing Cesarean Delivery During Labor.

Mauricio La Rosa, Victoria Jauk, George Saade, Kim Boggess, Sherri Longo, Erin A S Clark, Sean Esplin, Kirsten Cleary, Ronald Wapner, Kellett Letson and 6 more

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Obstetrics and gynecology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 19 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Mauricio La RosaDepartment of Obstetrics and Gynecology, the University of Texas Medical Branch, Galveston, Texas; the University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; the University of Alabama at Birmingham, Birmingham, Alabama; Oshner Health System, New Orleans, Louisiana; the University of Utah and Intermountain Health-LC, Salt Lake City, Utah; Columbia University, New York, New York; Mission Hospital, Asheville, North Carolina; the University of Mississippi at Jackson, Jackson, Mississippi, the University of Houston, Houston, Texas; and WakeMed Physician Practices, Raleigh, North Carolina.
Victoria Jauk
George Saade
Kim Boggess
Sherri Longo
Erin A S Clark
Sean Esplin
Kirsten Cleary
Ronald Wapner
Kellett Letson
Michelle Y Owens
Sean Blackwell
Jeff M Szychowski
William W Andrews
Alan T Tita
Cesarean Section Optimal Antibiotic Prophylaxis Trial Consortium
Intermountain Healthcare · US

Funding

Cesarean Section Optimal Antibiotic Prophylaxis (C/SOAP) TrialR01HD064729 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI TITA, ALAN THEVENET N. · 2010 to 2013
$2.8M
NICHD NIH HHS R01 HD064729
6 · The paper itself

Abstract

objectiveTo evaluate the association of institutional protocols for vaginal preparation with antiseptic solution and the surgical site infection rate in women undergoing cesarean delivery during labor.

methodsThis is a secondary analysis of a multicenter randomized controlled trial of adjunctive azithromycin prophylaxis for cesarean delivery performed in laboring patients with viable pregnancies. The primary outcome for this analysis was the rate of superficial or deep surgical site infection within 6 weeks postpartum, as per Centers for Disease Control and Prevention criteria. Maternal secondary outcomes included a composite of endometritis, wound infection or other infections, postoperative maternal fever, length of hospital stay, and the rates of hospital readmission, unexpected office visits, and emergency department visits.

resultsA total of 523 women delivered in institutions with vaginal antisepsis policies before cesarean delivery and 1,490 delivered in institutions without such policies. There was no difference in superficial and deep surgical site infection rates between women with and without vaginal preparation (5.5% vs 4.1%; odds ratio [OR] 1.38, 95% CI 0.87-2.17), even after adjusting for possible confounders (adjusted OR 0.86, 95% CI 0.43-1.73). The lack of significant benefit was noted in all other maternal secondary outcomes.

conclusionInstitutional policies for vaginal preparation before cesarean delivery were not associated with lower rates of surgical site infection in women undergoing cesarean delivery during labor.

Indexed as

Labor, ObstetricAntibiotic ProphylaxisAnti-Infective Agents, LocalCesarean SectionChlorhexidineEndometritisFemaleHumansInfant, NewbornNeonatal SepsisOdds RatioPovidone-IodinePregnancyPreoperative CareStreptococcus agalactiaeSurgical Wound InfectionAnti-Infective Agents, LocalChlorhexidinePovidone-Iodine

Identifiers

PMID29995743
PMCPMC6059990
OpenAlexW2831382032

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.