ArticleObstetrics and gynecology2018
Frequency of Opioid Dispensing After Vaginal Delivery.
Article in Obstetrics and gynecology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Capacitive-resistive radiofrequency therapy to treat postpartum perineal pain: A randomized study.PloS one · 2020Trial
- Associations between acute pain after vaginal delivery and postpartum opioid prescription fills: a retrospective case-controlled study.British journal of anaesthesia · 2024Article
- Risk of Death at 1 Year Following Postpartum Opioid Exposure.American journal of perinatology · 2024Article
- Nonsteroidal anti-inflammatory drug "allergy" labeling is associated with increased postpartum opioid utilization.The Journal of allergy and clinical immunology · 2024Article
- The risk of opioid use disorder among women undergoing obstetric-related procedures: Results from the Cerner Real-World Database.Drug and alcohol dependence reports · 2024Article
- Prescription of oxycodone versus codeine after childbirth and risk of persistent opioid use: a population-based cohort study.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2023Article
- Marijuana, Opioid, and Alcohol Use Among Pregnant and Postpartum Individuals Living With HIV in the US.JAMA network open · 2021Article
- The impact of race on postpartum opioid prescribing practices: a retrospective cohort study.BMC pregnancy and childbirth · 2021Article
- Patient Experience with Postpartum Pain Management in the Face of the Opioid Crisis.Journal of midwifery & women's health · 2021Observational
- Prescription opioid use after vaginal delivery and subsequent persistent opioid use and misuse.American journal of obstetrics & gynecology MFM · 2021Article
- Article
- Antidepressant Use around Conception, Prepregnancy Depression, and Risk of Ectopic Pregnancy.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2020Article
- Is opioid use safe in women trying to conceive?Epidemiology (Cambridge, Mass.) · 2020Article
- Opioid Prescription and Persistent Opioid Use After Ectopic Pregnancy.Obstetrics and gynecology · 2020Article
- Benzodiazepine use before conception and risk of ectopic pregnancy.Human reproduction (Oxford, England) · 2020Article
- Associations among Discharge Opioid Prescribing and Inpatient Postpartum Opioid Usage after Delivery.AJP reports · 2020Article
- Maternal and infant characteristics associated with maternal opioid overdose in the year following delivery.Addiction (Abingdon, England) · 2020Article
- Rates of New Persistent Opioid Use After Vaginal or Cesarean Birth Among US Women.JAMA network open · 2019Article
- Opioid prescribing after childbirth: overprescribing and chronic use.Current opinion in obstetrics & gynecology · 2019Review
- Prescription Opioid Dose After Vaginal Delivery and the Risk of Serious Opioid-Related Events: A Retrospective Cohort Study.Women's health issues : official publication of the Jacobs Institute of Women's HealthArticle
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo describe nationwide patterns in outpatient opioid dispensing after vaginal delivery.
methodsUsing the Truven Health Analytics MarketScan database, we performed a large, nationwide retrospective cohort study of commercially insured beneficiaries who underwent vaginal delivery between 2003 and 2015 and who were opioid-naive for 12 weeks before the delivery admission. We assessed the proportion of women dispensed an oral opioid within 1 week of discharge, the associated median oral morphine milligram equivalent dose dispensed, and the frequency of opioid refills during the 6 weeks after discharge. We evaluated predictors of opioid dispensing using multivariable logistic regression.
resultsAmong 1,345,244 women undergoing vaginal delivery, 28.5% were dispensed an opioid within 1 week of discharge. The most commonly dispensed opioids were hydrocodone (44.7%), oxycodone (34.6%), and codeine (13.1%). The odds of filling an opioid were higher among those using benzodiazepines (adjusted odds ratio [OR] 1.87, 95% CI 1.73-2.02) and antidepressants (adjusted OR 1.63, 95% CI 1.59-1.66), smokers (adjusted OR 1.44, 95% CI 1.38-1.51), and among those undergoing tubal ligation (adjusted OR 3.77, 95% CI 3.67-3.87), operative vaginal delivery (adjusted OR 1.52, 95% CI 1.49-1.54), and higher order perineal laceration (adjusted OR 2.15, 95% CI 2.11-2.18). The median (interquartile range, 10th-90th percentile) dose of opioids dispensed was 150 (113-225, 80-345) morphine milligram equivalents, equivalent to 20 tablets (interquartile range 15-30, 10th-90th percentile 11-46) of 5 mg oxycodone. Six weeks after discharge, 8.5% of women filled one or more additional opioid prescriptions.
conclusionOpioid dispensing after vaginal delivery is common and often occurs at high doses. Given the frequency of vaginal delivery, this may represent an important source of overprescription of opioids in the United States.
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