ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2018
Neuroendoscopic lavage for the treatment of CSF infection with hydrocephalus in children.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06358209 (Safety and Efficacy of Ventricular Irrigation for Ventriculitis), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Safety and Efficacy of Ventricular Irrigation for Ventriculitis: a Randomized Controlled Trial
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- A systematic review and meta-analysis of risk factors for reoperation after degenerative lumbar spondylolisthesis surgery.BMC surgery · 2023Pooled it
- Article
- Ventricular lavage versus conservative treatment in cerebral ventriculitis outcomes: a systematic review.Acta neurologica Belgica · 2025Review
- Clinical effect of radical debris evacuation with a flexible neuroendoscope on patients with ventriculitis: a case series.Journal of medical case reports · 2025Article
- A retrospective study on the efficacy of neuro-endoscopic lavage compared to conventional antibiotic treatment in pyogenic ventriculitis.Neurosurgical review · 2025Article
- Article
- Surgical Antimicrobial Prophylaxis in Neonates and Children Undergoing Neurosurgery: A RAND/UCLA Appropriateness Method Consensus Study.Antibiotics (Basel, Switzerland) · 2022Article
- Neuroendoscopic lavage for the treatment of pyogenic ventriculitis in children: personal series and review of the literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Review
- Neuroendoscopic surgery in neonates - indication and results over a 10-year practice.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Integrated understanding of hydrocephalus - a practical approach for a complex disease.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Review
- Surgical treatment of post-infectious hydrocephalus in infants.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Predictor of a permanent shunt after treatment of external ventricular draining in pediatric postinfective hydrocephalus-a retrospective cohort study.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Intrathecal Antibacterial and Antifungal Therapies.Clinical microbiology reviews · 2020Review
- Bedside placement of ventricular access devices under local anaesthesia in neonates with posthaemorrhagic hydrocephalus: preliminary experience.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe treatment of infectious CSF condition with ventriculitis and hydrocephalus in children is an interdisciplinary challenge. Conventional surgical treatment includes external ventricular drain (EVD) and systemic antibiotic therapy. However, infectious contamination of large ventricles combined with CSF protein overload often requires long treatment regimens. We retrospectively investigated neuroendoscopic lavage as a new option for clearance of CSF in children with hydrocephalus and active CSF infection. PATIENTS AND
methodsA database review identified 50 consecutive patients treated for CSF infection with hydrocephalus at our institution. Twenty-seven patients (control group, CG) were treated conventionally between 2004 and 2010, while 23 patients (neuroendoscopic group, NEG) underwent neuroendoscopic lavage for removal of intraventricular debris between 2010 and 2015. Clinical data, microbiology, laboratory measures, shunt dependency, and shunt revision rate were evaluated retrospectively.
resultsThe patient groups did not differ regarding basic clinical characteristics. Patients in NEG received neuroendoscopic lavage at mean of 1.6 ± 1times (1-4). No immediate postoperative complications were observed in NEG patients. Shunt rate in NEG patients was 91% as compared 100% in CG patients (p = 0.109). Within 24 months after shunt implantation, incidence of shunt revision was higher in CG (23/27) compared to NEG (5/23; p < 0.001). Reinfection was observed more often in CG (n = 17) compared to one patient in NEG (p < 0.001).
conclusionsWe experienced that neuroendoscopic lavage is a safe and effective treatment for hydrocephalus in children with infectious conditions. Neuroendoscopic lavage resulted in a decreased number of overall shunt revisions in shunt-depended patients as well as a lower number of recurrent infections.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.