ArticleJournal of assisted reproduction and genetics2018
Abnormal sperm concentration and motility as well as advanced paternal age compromise early embryonic development but not pregnancy outcomes: a retrospective study of 1266 ICSI cycles.
Article in Journal of assisted reproduction and genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07369362 (A Multicenter Randomized Controlled Non-Inferiority Trial Comparing SwimCount Harvester® to Standard Sperm Preparation Methods in IVF Cycles With PGT-A), which is not on this map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multicenter Randomized Controlled Non-Inferiority Trial Comparing SwimCount Harvester® to Standard Sperm Preparation Methods in IVF Cycles With PGT-A
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Fertility in the aging male: a systematic review.Fertility and sterility · 2022Pooled it
- Preimplantation genetic testing for male factor infertility: lights and shadows.Journal of endocrinological investigation · 2026Review
- Shortened warming protocols preserve spindle integrity and mitochondrial mass less effectively than standard warming in autologous oocytes cryopreserved via standard vitrification.Journal of assisted reproduction and genetics · 2026Article
- Evaluating Sperm DNA Damage: When and Why It Adds to the Management of the Infertile Man.Advances in experimental medicine and biology · 2026Review
- Demographic and clinical associations with miscarriage and unsuccessful conception attempts among female Syrian refugees in Lebanon.BMC pregnancy and childbirth · 2025Article
- Sperm DNA fragmentation index: limited effectiveness on predicting embryo quality in assisted reproduction technology treatments.Reproductive biology and endocrinology : RB&E · 2025Article
- Do different male infertility factors impact embryological, cumulative pregnancy and neonatal outcomes in IVF/ICSI cycles? A retrospective cohort study.Human reproduction open · 2025Article
- Impact of advanced paternal age on reproductive outcomes in preimplantation genetic testing cycles of young female: a retrospective cohort study.Frontiers in reproductive health · 2025Article
- Trophectoderm, Inner Cell Mass, and Expansion Status for Live Birth Prediction After Frozen Blastocyst Transfer: The Winner Is Trophectoderm.Life (Basel, Switzerland) · 2024Article
- Article
- Too many embryos: a critical perspective on a global challenge.Journal of assisted reproduction and genetics · 2024Article
- To Assess or Not to Assess: Reconsidering Day 3 Embryo Quality in Planned Freeze-All Blastocyst Cycles.Journal of personalized medicine · 2024Article
- Advanced Paternal Age in Focus: Unraveling Its Influence on Assisted Reproductive Technology Outcomes.Journal of clinical medicine · 2024Review
- Male factor infertility and assisted reproductive technologies: indications, minimum access criteria and outcomes.Journal of endocrinological investigation · 2023Review
- In Vitro Fertilisation and Intracytoplasmic Sperm Injection predictive factors: A review of the effect of female age, ovarian reserve, male age, and male factor on IVF/ICSI treatment outcomes.JBRA assisted reproduction · 2023Review
- Conventional IVF performs similarly in women with and without endometriosis.Journal of assisted reproduction and genetics · 2023Article
- Dietary flaxseed oil and vitamin E improve semen qualityFrontiers in endocrinology · 2023Article
- Reproductive axis ageing and fertility in men.Reviews in endocrine & metabolic disorders · 2022Review
- Effect of advanced parental age on pregnancy outcome and offspring health.Journal of assisted reproduction and genetics · 2022Review
- Impact of ejaculatory abstinence period and semen characteristic on the reproductive outcomes after intracytoplasmic sperm injection.JBRA assisted reproduction · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the effect of sperm concentration, motility and advanced paternal age on reproductive outcomes.
methodsA retrospective analysis of 1266 intracytoplasmic sperm injection (ICSI) cycles between 2013 and 2017. The cohort was divided into four groups according to semen concentration based on the WHO criteria (2010): group A (conc. <1 M/ml), group B (1 ≤ conc. <5 M/ml), group C (5 ≤ conc. < 15 M/ml) and the control group D (conc. ≥15 M/ml). The primary outcome investigated was the blastulation rate. Secondary outcomes were fertilization rate, top quality blastocyst formation rate and ongoing pregnancy rate.
resultsAfter adjustment for maternal age and number of oocytes recovered, a significant difference was observed between group A and group D on the rate of fertilized oocytes [66.7 (40.0-80.0) vs 75.0 (57.1-90.2), adjusted p < 0.001] and the blastocyst formation rate [50.0 (33.3-66.3) vs 55.6 (40.0-75.0), adjusted p < 0.05]. However, the male factor did not affect the top quality blastocyst formation rate nor the ongoing pregnancy rate. Considering the age of the male partner as confounding factor, at the increase of each year of age, a reduction of 0.3% on the fertilization rate was observed but no other outcome was impacted. A negative correlation was also observed between sperm motility and fertilization rate in the group with a motility <5%.
conclusionMale factor infertility and advanced paternal age may compromise fertilization and blastulation rates but not top quality blastocyst formation rate or the establishment of pregnancy in ICSI cycles.
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