Evidence map›Paper›PMID 29995195›Full record

ArticleJapanese journal of ophthalmology2018

Visual function and inner retinal structure correlations in aquaporin-4 antibody-positive optic neuritis.

Nattapong Mekhasingharak, Niphon Chirapapaisan, Poramaet Laowanapiban, Sasitorn Siritho, Naraporn Prayoonwiwat, Chanjira Satukijchai, Jiraporn Jitprapaikulsan, Pornsawan Mekhasingharak, Siriraj Neuroimmunology Research Group

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Article in Japanese journal of ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Nattapong MekhasingharakDepartment of Ophthalmology, Naresuan University Hospital, Naresuan University, Phitsanulok, Thailand.
Niphon ChirapapaisanDepartment of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. niphon.chi@mahidol.ac.th.
Poramaet LaowanapibanDepartment of Ophthalmology, Mettapracharak Hospital, Nakhon Pathom, Thailand.
Sasitorn SirithoDivision of Neurology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Naraporn PrayoonwiwatDivision of Neurology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Chanjira SatukijchaiDivision of Neurology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Jiraporn JitprapaikulsanDivision of Neurology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Pornsawan MekhasingharakDivision of Neurology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Siriraj Neuroimmunology Research Group
Mahidol University · THBangkok Hospital · THCharoenkrung Pracharak Hospital · THNaresuan University Hospital · THSiriraj Hospital · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the correlation between visual function and thinning of the retinal nerve fiber layer (RNFL) and the macular ganglion cell-inner plexiform layer (GCIPL) as measured by optical coherence tomography (OCT) in eyes with aquaporin-4 IgG-positive optic neuritis (AQP4-IgG-positive ON). STUDY

designProspective study.

methodsPatients with a history of ON were categorized into 2 groups: the AQP4-IgG-positive group and the AQP4-IgG-negative group. Patients with multiple sclerosis were excluded. All patients underwent ophthalmologic examination and OCT imaging at least 6 months after the last episode of acute ON. Visual function and inner retinal structure correlations were analyzed using Pearson correlation and regression analyses.

resultsThirty-one previous ON eyes of 17 AQP4-IgG-positive patients and 21 previous ON eyes of 15 AQP4-IgG-negative patients were registered. Visual function, especially the visual field, was better correlated with RNFL than with macular GCIPL. The best correlation between visual function and RNFL was the linear model, whereas the best correlation between visual function and GCIPL was the nonlinear model (inverse regression). Regression models revealed worse visual function in AQP4-IgG-positive ON than in AQP4-IgG-negative ON, whereas no differences in RNFL and GCIPL were found between the 2 groups.

conclusionsRNFL measured by OCT can be a useful retinal structure for estimating and monitoring visual field loss in AQP4-IgG-positive ON patients, particularly in patients whose visual field cannot be quantitated. The correlation between visual function and the inner retinal structure of eyes with AQP4-IgG is unique and differs from that of eyes without AQP4-IgG.

Indexed as

Visual AcuityVisual FieldsAdultAgedAquaporin 4AutoantibodiesFemaleFollow-Up StudiesHumansMaleMiddle AgedNerve FibersOptic NeuritisProspective StudiesRetinal Ganglion CellsTomography, Optical CoherenceAquaporin 4AutoantibodiesAquaporin-4 antibodyNeuromyelitis opticaOptical coherence tomographyOptic neuritisVisual function

Identifiers

PMID29995195
OpenAlexW2860104231

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.