ArticleJournal of applied oral science : revista FOB2018
Effects of platelet-rich plasma on human gingival fibroblast proliferation and migration in vitro.
Article in Journal of applied oral science : revista FOB, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Cord Blood-Derived Versus Homologous Donor Platelet-Rich Plasma (PRP) in Early Knee Osteoarthritis: A Single-Center, Randomized, Double-Blind Pilot Clinical Trial.Bioengineering (Basel, Switzerland) · 2026Article
- Refrigerated storage of L-PRF membranes: anti-bacterial activity, cytokine release, andFrontiers in oral health · 2026Article
- Polyprenylated Acylphloroglucinols fromPharmaceuticals (Basel, Switzerland) · 2025Article
- Between Promise and Proof: Evaluating PRP's Role in Modern Gynecology.Medicina (Kaunas, Lithuania) · 2025Review
- Application of Platelet-Rich Plasma in Gynaecologic Disorders: A Scoping Review.Journal of clinical medicine · 2025Review
- Review
- Novel platelet-rich plasma/ hyaluronic acid lyophilized formulations for wound healing applications.Frontiers in bioengineering and biotechnology · 2025Article
- Platelet-rich Plasma in Orthopedics: Unraveling Cellular Mechanisms, Therapeutic Potential, and Limitations : Platelet-rich Plasma in Orthopedics.Galen medical journal · 2025Review
- Experimental Investigation of the Effects of Photobiomodulation Therapy on the Viability, Migration, and Gene Expression of Human Gingival Fibroblasts.Journal of lasers in medical sciences · 2025Article
- Platelet-Rich Plasma (PRP) Based on Simple and Efficient Integrated Preparation Precises Quantitatively for Skin Wound Repair.International journal of molecular sciences · 2024Article
- Optimizing collagen-based biomaterials for periodontal regeneration: clinical opportunities and challenges.Frontiers in bioengineering and biotechnology · 2024Review
- Angiogenesis and Tissue Repair Depend on Platelet Dosing and Bioformulation Strategies Following Orthobiological Platelet-Rich Plasma Procedures: A Narrative Review.Biomedicines · 2023Review
- Modifying Orthobiological PRP Therapies Are Imperative for the Advancement of Treatment Outcomes in Musculoskeletal Pathologies.Biomedicines · 2022Review
- [Platelet-rich plasma (PRP) for the treatment of androgenetic alopecia (AGA): a review of the current literature].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2022Review
- PRP and PRF-Subgroups and Divisions When Used in Dentistry.Journal of personalized medicine · 2021Review
- The Effect of Platelet-Rich Plasma on the Intra-Articular Microenvironment in Knee Osteoarthritis.International journal of molecular sciences · 2021Review
- Effect of Butyric Acid in the Proliferation and Migration of Junctional Epithelium in the Progression of Periodontitis: An In Vitro Study.Dentistry journal · 2021Article
- Therapeutic candidates for keloid scars identified by qualitative review of scratch assay research for wound healing.PloS one · 2021Review
- Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020.International journal of molecular sciences · 2020Review
- Leucocyte-Rich Platelet-Rich Plasma Enhances Fibroblast and Extracellular Matrix Activity: Implications in Wound Healing.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study evaluated the influence of platelet-rich plasma (PRP) on the behaviour of human gingival fibroblasts (hGFs), including fibroblast proliferation, migration and colony formation.
methodsPRP was obtained from the human peripheral blood of a healthy volunteer and then was diluted into platelet concentrations of 1%, 2% and 5%. The proliferation of hGFs was determined by two methods: (1) Cell-number counting with a haemocytometer method at days 1, 3, 5 and 7; (2) Colony-forming unit-fibroblast (CFU-F) assay at 2 weeks. The migration of hGFs was evaluated with scratch assay, then recorded digital images were analysed by Image-Analysis J 1.51j8 software to compare the remaining artificial wound areas between PRP groups at 0, 24 and 48 hours.
resultsAll hGFs that were cultivated in media with 1%, 2% and 5% PRP showed their ability to proliferate and migrate. Cell numbers incubated with 1% PRP increased significantly during the first three days and peaked at day 5, tending to be similar to their proliferation in complete medium. With concentrations of 2% and 5% PRP, hGFs outgrew and peaked at day 3, which was faster than with those in medium with 1% PRP. Especially, hGFs in the group 5% PRP proliferated with higher cell numbers than those in the other remaining groups at day 3. The hGF colony number that was formed in the group 5% PRP was significantly higher than those in the groups 1% and 2% PRP. Scratch assay showed hGFs in the groups 2% and 5% PRP almost filled the artificial wound and migrated more effectively than in the group 1% PRP at 24 hours, which was significant.
conclusionIn this study, perhaps the medium with 5% PRP is the dominant option, promoting the abilities of hGFs to heal wounds, because of its fast and effective impact on cell proliferation, colony formation and migration.
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