ArticleThe international journal of occupational and environmental medicine2018
Pesticide Exposure and Thyroid Function in Elementary School Children Living in an Agricultural Area, Brebes District, Indonesia.
Article in The international journal of occupational and environmental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Exposure to pesticides and the risk of hypothyroidism: a systematic review and meta-analysis.BMC public health · 2023Pooled it
- Prevalence of goitre and iodine deficiency among school children (6-12 years) in rural areas of North Karnataka, India: A cross-sectional survey, 2016-19.Journal of family medicine and primary care · 2023Article
- Frequency of urinary pesticides in children: a scoping review.Frontiers in public health · 2023Article
- Additives in Children's Nutrition-A Review of Current Events.International journal of environmental research and public health · 2022Review
- Farmers' knowledge and practice regarding good agricultural practices (GAP) on safe pesticide usage in Indonesia.Heliyon · 2022Article
- Comparison of Thyroid Hormone Levels between Women Farmers and Non-Farmers in Banten Indonesia.International journal of environmental research and public health · 2021Article
- Acetylcholinesterase activity and thyroid hormone levels in Ecuadorian adolescents living in agricultural settings where organophosphate pesticides are used.International journal of hygiene and environmental health · 2021Article
- Longitudinal Study of Thyroid Hormones between Conventional and Organic Farmers in Thailand.Toxics · 2020Article
- Reduced neurobehavioral functioning in agricultural workers and rural inhabitants exposed to pesticides in northern Chile and its association with blood biomarkers inhibition.Environmental health : a global access science source · 2020Article
- The Relationship between Pesticide Exposure and Umbilical Serum IGF-1 Levels and Low-birth Weight: A Case-control Study in Brebes, Indonesia.The international journal of occupational and environmental medicine · 2020Article
- Pesticide Exposure and Stunting among Children in Agricultural Areas.The international journal of occupational and environmental medicine · 2019Article
- Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data.Frontiers in endocrinology · 2019Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChildren living in agricultural areas are at risk of exposure to pesticides due to their involvement in agricultural activities. Pesticides are one of the chemicals classified as endocrine disrupting chemicals.
objectiveTo examine the association between exposure to organophosphate pesticides and the occurrence of thyroid dysfunction in children.
methodsThis cross-sectional study was conducted on 66 children in two elementary schools located in an agricultural area in Brebes District, Indonesia, in 2015. To determine the pesticide exposure history, we analyzed urine samples and completed a questionnaire. Meanwhile, thyroid function tests were performed.
resultsOrganophosphate pesticide metabolites were detected in urine samples of 15 (23%) of 66 children. Thyroid stimulating hormone (TSH) levels >4.5 μIU/mL were detected in 24 (36%) children. Free thyroxine (FT4) levels of all participants were normal. The mean TSH level in children with positive urinary organophosphate pesticide metabolites (7.74 μIU/ mL) was significantly (p=0.005) higher than that in those who were negative (4.34 μIU/mL). The prevalence of hypothyroidism in children with positive urinary organophosphate pesticide metabolites (67%) was significantly higher than that in those who were negative (27%; PR 2.4, 95% CI 1.4 to 4.3).
conclusionA history of pesticide exposure could be used as a risk factor for the occurrence of thyroid dysfunction in children living in agricultural areas.
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