Evidence map›Paper›PMID 29994984›Full record

ArticleTransplantation2018

Evolutionary Distance Predicts Recurrence After Liver Transplantation in Multifocal Hepatocellular Carcinoma.

Nils Heits, Mario Brosch, Alexander Herrmann, Robin Behrens, Christoph Röcken, Harald Schrem, Alexander Kaltenborn, Jürgen Klempnauer, Hans-Heinrich Kreipe, Benedikt Reichert and 20 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Nils HeitsDepartment of General, Visceral-, Thoracic-, Transplantation- and Pediatric Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Germany.
Mario BroschMedical Department 1, University Hospital Dresden, TU Dresden, Dresden, Germany.
Alexander HerrmannMedical Department 1, University Hospital Dresden, TU Dresden, Dresden, Germany.
Robin BehrensDepartment of General, Visceral-, Thoracic-, Transplantation- and Pediatric Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Germany.
Christoph RöckenInstitute for Pathology, University Hospital Schleswig-Holstein, Campus Kiel, Germany.
Harald SchremDepartment of General, Visceral and Transplant Surgery, Hannover Medical School, Hannover, Germany.
Alexander KaltenbornCore Facility Quality Management and Health Technology Assessment in Transplantation, Integrated Research Treatment Center-Transplantation (IFB-Tx), Hannover Medical School, Hannover, Germany.
Jürgen KlempnauerDepartment of General, Visceral and Transplant Surgery, Hannover Medical School, Hannover, Germany.
Hans-Heinrich KreipeInstitute of Pathology, Hannover Medical School, Hannover, Germany.
Benedikt ReichertDepartment of General, Visceral-, Thoracic-, Transplantation- and Pediatric Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Germany.
Christina LenschowDepartment of General Surgery and Visceral Surgery, University Hospital of Muenster, Muenster, Germany.
Christian WilmsClinic for Transplantation Medicine, University Hospital of Muenster, Muenster, Germany.
Thomas VogelDepartment of General Surgery and Visceral Surgery, University Hospital of Muenster, Muenster, Germany.
Heiner WoltersDepartment of General Surgery and Visceral Surgery, University Hospital of Muenster, Muenster, Germany.
Eva WardelmannDepartment of Pathology, University Hospital of Muenster, Muenster, Germany.
Daniel SeehoferDepartment of General, Visceral, and Transplantation Surgery, Charité, Campus Virchow Klinikum, Berlin, Germany.
Stephan BuchMedical Department 1, University Hospital Dresden, TU Dresden, Dresden, Germany.
Sebastian ZeissigMedical Department 1, University Hospital Dresden, TU Dresden, Dresden, Germany.
Sven PannachMedical Department 1, University Hospital Dresden, TU Dresden, Dresden, Germany.
Nathanael RaschzokDepartment of General, Visceral, and Transplantation Surgery, Charité, Campus Virchow Klinikum, Berlin, Germany.
Manfred DietelInstitute of Pathology, Charité University Hospital, Berlin, Germany.
Witigo von SchoenfelsDepartment of General, Visceral-, Thoracic-, Transplantation- and Pediatric Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Germany.
Sebastian HinzDepartment of General, Visceral-, Thoracic-, Transplantation- and Pediatric Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Germany.
Andreas TeufelDepartment of Medicine, University Hospital Regensburg, Regensburg, Germany.
Matthias EvertInstitute of Pathology, University of Regensburg, Regensburg, Germany.
Andre FrankeInstitute for Clinical Molecular Biology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Thomas BeckerDepartment of General, Visceral-, Thoracic-, Transplantation- and Pediatric Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Germany.
Felix BraunDepartment of General, Visceral-, Thoracic-, Transplantation- and Pediatric Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Germany.
Jochen HampeMedical Department 1, University Hospital Dresden, TU Dresden, Dresden, Germany.
Clemens SchafmayerDepartment of General, Visceral-, Thoracic-, Transplantation- and Pediatric Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLiver transplantation (LTx) is a potentially curative treatment option for hepatocellular carcinoma (HCC) in cirrhosis. However, patients, where HCC is already a systemic disease, LTx may be individually harmful and has a negative impact on donor organ usage. Thus, there is a need for improved selection criteria beyond nodule morphology to select patients with a favorable outcome for LTx in multifocal HCC. Evolutionary distance measured from genome-wide single-nucleotide polymorphism data between tumor nodules and the cirrhotic liver may be a prognostic marker of survival after LTx for multifocal HCC.

methodsIn a retrospective multicenter study, clinical data and formalin-fixed paraffin-embedded specimens of the liver and 2 tumor nodules were obtained from explants of 30 patients in the discovery and 180 patients in the replication cohort. DNA was extracted from formalin-fixed paraffin-embedded specimens followed by genome wide single-nucleotide polymorphism genotyping.

resultsGenotype quality criteria allowed for analysis of 8 patients in the discovery and 17 patients in the replication set. DNA concentrations of a total of 25 patients fulfilled the quality criteria and were included in the analysis. Both, in the discovery (P = 0.04) and in the replication data sets (P = 0.01), evolutionary distance was associated with the risk of recurrence of HCC after transplantation (combined P = 0.0002). In a univariate analysis, evolutionary distance (P = 7.4 × 10) and microvascular invasion (P = 1.31 × 10) were significantly associated with survival in a Cox regression analysis.

conclusionsEvolutionary distance allows for the determination of a high-risk group of recurrence if preoperative liver biopsy is considered.

Indexed as

Liver TransplantationAdultBiomarkersBiopsyCarcinoma, HepatocellularEvolution, MolecularFemaleFollow-Up StudiesGenotyping TechniquesHumansLiver CirrhosisLiver NeoplasmsMaleMiddle AgedNeoplasm Recurrence, LocalPatient SelectionBiomarkers

Identifiers

PMID29994984
PMCPMC7598094

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.