Evidence map›Paper›PMID 29994914›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2018

A Global Research Agenda for Pediatric HIV.

Martina Penazzato, Cadi Irvine, Marissa Vicari, Shaffiq M Essajee, Aditi Sharma, Thanyawee Puthanakit, Elaine J Abrams, Meg Doherty

Abstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Trial
  2. Trial
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  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Roadmap for Achieving Universal Antiretroviral Treatment.Annual review of pharmacology and toxicology · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. The application of clinical genetics · 2019
    Article
  18. Making Implementation Science Work for Children and Adolescents Living With HIV.Journal of acquired immune deficiency syndromes (1999) · 2018
    Article
  19. Ensuring Children and Adolescents Are Not Left Behind.Journal of acquired immune deficiency syndromes (1999) · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Martina PenazzatoDepartment of HIV and Global Hepatitis Programme, World Health Organization, Geneva, Switzerland.
Cadi IrvineDepartment of HIV and Global Hepatitis Programme, World Health Organization, Geneva, Switzerland.
Marissa VicariDepartment of HIV Programmes and Advocacy, International AIDS Society, Geneva, Switzerland.
Shaffiq M EssajeeHIV Section, Program Division, UNICEF, New York, NY.
Aditi SharmaGlobal Network of People Living with HIV (GNP+).
Thanyawee PuthanakitDepartment of Pediatrics, Center of Excellence in Pediatric Infectious Diseases and Vaccine, Faculty of Medicine, Chulalongkorn University.
Elaine J AbramsICAP at Columbia University, Mailman School of Public Health, and College of Physicians & Surgeons, Columbia University, New York, NY.
Meg DohertyDepartment of HIV and Global Hepatitis Programme, World Health Organization, Geneva, Switzerland.

Funding

World Health Organization 001
6 · The paper itself

Abstract

backgroundDespite progress, 2016 still saw 160,000 new infections and 120,000 AIDS-related deaths among children. Evidence gaps on how to best diagnose, treat, and deliver services to children living with HIV remain. A global research prioritization exercise was undertaken by WHO and CIPHER to focus research efforts in the context of diminishing resources.

methodsThe Child Health and Nutrition Research Initiative methodology was adapted and used, as described by Irvine et al. Outcomes were reviewed by an expert group and 5 priority themes identified for testing, antiretroviral treatment, and service delivery, accounting for existing policies, published literature and ongoing research.

resultsA total of 749 questions were submitted by 269 individuals from 62 countries. For HIV testing, priority themes included strategies and interventions to improve access, uptake and linkage to care, including with novel diagnostic tools and entry points beyond antenatal care. For treatment, priorities included strategies to improve adherence, short- and long-term outcomes and management of coinfections, optimal drug formulations, and early ART. For service delivery, priorities included strategies or interventions to improve access, uptake and retention in care, including psychosocial and family support and approaches to HIV disclosure and reduction of stigma and discrimination.

conclusionsThis is the largest Child Health and Nutrition Research Initiative exercise undertaken in HIV. The results provide guidance to focus future research in pediatric HIV for impact. Global commitment to support priority research, adequate investment, and strong leadership is urgently needed to improve the health and well-being of children living with and affected by HIV.

Indexed as

Biomedical ResearchChild HealthGlobal HealthAnti-Retroviral AgentsChildDiscrimination, PsychologicalDisease EradicationHIVHIV InfectionsHumansMass ScreeningNutritional SciencesPediatricsSocial StigmaAnti-Retroviral Agents

Identifiers

PMID29994914
PMCPMC6075892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.