Evidence map›Paper›PMID 29994832›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2018

Beyond Early Infant Diagnosis: Changing the Approach to HIV-Exposed Infants.

Surbhi Modi, Laura N Broyles, Michele Montandon, Megumi Itoh, Boniface Ochanda, Agnes Langat, David Sullivan, Helen Dale

Abstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Surbhi ModiDivision of Global HIV and TB (DGHT), Centers for Disease Control and Prevention (CDC), Atlanta, GA.
Laura N BroylesDivision of Global HIV and TB (DGHT), Centers for Disease Control and Prevention (CDC), Atlanta, GA.
Michele MontandonDivision of Global HIV and TB (DGHT), Centers for Disease Control and Prevention (CDC), Atlanta, GA.
Megumi ItohDivision of Global HIV and TB (DGHT), Centers for Disease Control and Prevention (CDC), Atlanta, GA.
Boniface OchandaDGHT, CDC, Nairobi, Kenya; and.
Agnes LangatDGHT, CDC, Nairobi, Kenya; and.
David SullivanOffice of HIV/AIDS, United States Agency for International Development.
Helen DaleDivision of Global HIV and TB (DGHT), Centers for Disease Control and Prevention (CDC), Atlanta, GA.

Funding

Intramural CDC HHS CC999999PEPFAR
6 · The paper itself

Abstract

Despite dramatic global progress with implementing prevention of mother-to-child HIV transmission (PMTCT) programs, there were 160,000 new pediatric HIV infections in 2016. More than 50% of infant HIV infections now occur in the postpartum period, reflecting the relatively high coverage of interventions in the antenatal period and the need for greater attention to the breastfeeding mother and her HIV-exposed infant (HEI). Early diagnosis and treatment are critical to prevent morbidity and mortality in HIV-infected children; however, early infant HIV testing rates remain low in most high HIV-burden countries. Furthermore, systematic retention and follow-up of HEI in the postpartum period and ascertainment of final HIV status remain major program gaps. Despite multiple calls to action to improve infant HIV testing rates, progress has been marginal due to a lack of focus on the critical health care needs of HEI coupled with health system barriers that result in fragmented services for HIV-infected mothers and their families. In this paper, we describe the available evidence on the health outcomes of HEI, define a comprehensive care package for HEI that extends beyond early HIV testing, and describe successful examples of integrated services for HEI.

Indexed as

Early DiagnosisFemaleHIVHIV InfectionsHumansInfantInfant, NewbornInfectious Disease Transmission, VerticalMaleMaternal Health ServicesPostpartum PeriodPregnancyPregnancy Complications, InfectiousPrenatal Diagnosis

Identifiers

PMID29994832
PMCPMC6401209

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.