Evidence map›Paper›PMID 29994830›Full record

ReviewJournal of acquired immune deficiency syndromes (1999)2018

Family Testing: An Index Case Finding Strategy to Close the Gaps in Pediatric HIV Diagnosis.

Katherine R Simon, Robert J Flick, Maria H Kim, Rachael A Sabelli, Tapiwa Tembo, Benjamin Ryan Phelps, Nora E Rosenberg, Saeed Ahmed

Abstract readReview
In one paragraph

Review in Journal of acquired immune deficiency syndromes (1999), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Katherine R SimonBaylor College of Medicine Children's Foundation Malawi, Lilongwe, Malawi.
Robert J FlickBaylor College of Medicine Children's Foundation Malawi, Lilongwe, Malawi.
Maria H KimBaylor College of Medicine Children's Foundation Malawi, Lilongwe, Malawi.
Rachael A SabelliBaylor College of Medicine Children's Foundation Malawi, Lilongwe, Malawi.
Tapiwa TemboBaylor College of Medicine Children's Foundation Malawi, Lilongwe, Malawi.
Benjamin Ryan PhelpsUnited States Agency for International Development, Washington, DC; and.
Nora E RosenbergDepartment of Health Behavior, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC.
Saeed AhmedBaylor College of Medicine Children's Foundation Malawi, Lilongwe, Malawi.
Texas Children's Hospital · USUnited States Agency for International Development · USUniversity of North Carolina at Chapel Hill · US

Funding

Developing and Assessing a Male Engagement Intervention for Option B+ in MalawiR00MH104154 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROSENBERG, NORA · 2017 to 2019
$746k
Improving prevention of mother-to-child HIV transmission outcomes in MalawiK01TW009644 · FIC · BAYLOR COLLEGE OF MEDICINE · PI KIM, MARIA HYOUN · 2013 to 2017
$663k
FIC NIH HHS K01 TW009644NIMH NIH HHS R00 MH104154
6 · The paper itself

Abstract

Despite significant advances in pediatric HIV treatment, too many children remain undiagnosed and thus without access to lifesaving antiretroviral therapy. It is critical to identify these children and initiate antiretroviral therapy as early as possible. Although the children of HIV-infected adults are at higher risk of infection, few access HIV testing services because of missed opportunities in existing case finding programs. Family testing is an index case finding strategy through which HIV-infected patients are systematically screened to identify family members with unknown HIV status. By specifically targeting a high-risk population, family testing is a pragmatic, high-yield, and efficient approach to identify previously undiagnosed HIV-infected children and link them to care before they become symptomatic. Despite this, incorporation of family testing into national guidelines and implementation of this case finding approach is variable. In this article, we review the evidence base for family testing, describe its challenges, and provide guidance and sample tools for program managers aiming to integrate family testing into existing health systems.

Indexed as

Anti-Retroviral AgentsChildEarly DiagnosisFamilyFemaleHealth Services ResearchHIV InfectionsHumansMaleMass ScreeningPediatricsAnti-Retroviral Agents

Identifiers

PMID29994830
PMCPMC6047763
OpenAlexW2875622141

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.