Evidence map›Paper›PMID 29994656›Full record

ArticleIEEE transactions on medical imaging2018

Blind Source Separation-Based Motion Detector for Imaging Super-Paramagnetic Iron Oxide (SPIO) Particles in Magnetomotive Ultrasound Imaging.

Md Murad Hossain, Benjamin E Levy, Diwash Thapa, Amy L Oldenburg, Caterina M Gallippi

Abstract read
In one paragraph

Article in IEEE transactions on medical imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Single Magnetic Particle Motion in Magnetomotive Ultrasound: An Analytical Model and Experimental Validation.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Md Murad Hossain
Benjamin E Levy
Diwash Thapa
Amy L Oldenburg
Caterina M Gallippi

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
Transcutaneous ARFI Ultrasound for Differentiating Carotid Plaque with High Stroke RiskR01HL092944 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GALLIPPI, CATERINA M · 2009 to 2022
$5.5M
VisR Ultrasound for Noninvasively Monitoring Renal Allograft HealthR01DK107740 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Caterina M Gallippi · 2016 to 2026
$5.2M
DP ARF Ultrasound for Monitoring Muscle Degeneration in Duchenne Muscular DystropR01NS074057 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GALLIPPI, CATERINA M · 2011 to 2015
$2.0M
Developing Contrast-Enhanced Ultrasound of Thrombosis via SPIO-RL PlateletsR21HL119928 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI OLDENBURG, AMY L · 2014 to 2015
$411k
Novel Device for Sensitive, Small Sample Volume Assessment of Clot ElasticityR21HL109832 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI OLDENBURG, AMY L · 2011 to 2012
$371k
NHLBI NIH HHS R01 HL092944NHLBI NIH HHS R21 HL109832NHLBI NIH HHS R21 HL119928NIDDK NIH HHS R01 DK107740NIEHS NIH HHS P30 ES010126NINDS NIH HHS R01 NS074057
6 · The paper itself

Abstract

In magnetomotive ultrasound (MMUS) imaging, an oscillating external magnetic field displaces tissue loaded with super-paramagnetic iron oxide (SPIO) particles. The induced motion is on the nanometer scale, which makes its detection and its isolation from background motion challenging. Previously, a frequency and phase locking (FPL) algorithm was used to suppress background motion by subtracting magnetic field off ( -off) from on ( -on) data. Shortcomings to this approach include long tracking ensembles and the requirement for -off data. In this paper, a novel blind source separation-based FPL (BSS-FPL) algorithm is presented for detecting motion using a shorter ensemble length (EL) than FPL and without -off data. MMUS imaging of two phantoms containing an SPIO-laden cubical inclusion and one control phantom was performed using an open-air MMUS system. When background subtraction was used, contrast and contrast to noise ratio (CNR) were, respectively, 1.20±0.20 and 1.56±0.34 times higher in BSS-FPL as compared to FPL-derived images for EL < 3.5 s. However, contrast and CNR were similar for BSS-FPL and FPL for EL ≥ 3.5 s. When only -on data was used, contrast and CNR were 1.94 ± 0.21 and 1.56 ± 0.28 times higher, respectively, in BSS-FPL as compared to FPL-derived images for all ELs. Percent error in the estimated width and height was 39.30% ± 19.98% and 110.37% ± 6.5% for FPL and was 7.30% ± 7.6% and 16.21% ± 10.29% for BSS-FPL algorithm. This paper is an important step toward translating MMUS imaging to in vivo application, where long tracking ensembles would increase acquisition time and -off data may be misaligned with -on due to physiological motion.

Indexed as

AlgorithmsEquipment DesignMagnetite NanoparticlesPhantoms, ImagingPrincipal Component AnalysisUltrasonographyMagnetite Nanoparticles

Identifiers

PMID29994656
PMCPMC6239419

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.