Evidence map›Paper›PMID 29994592›Full record

ArticleIEEE journal of biomedical and health informatics2019

Accounting for Label Uncertainty in Machine Learning for Detection of Acute Respiratory Distress Syndrome.

Narathip Reamaroon, Michael W Sjoding, Kaiwen Lin, Theodore J Iwashyna, Kayvan Najarian

Abstract read
In one paragraph

Article in IEEE journal of biomedical and health informatics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Multimodal Deep Learning for ARDS Detection.medRxiv : the preprint server for health sciences · 2025
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  20. Machine Learning Classifier Models: The Future for Acute Respiratory Distress Syndrome Phenotyping?American journal of respiratory and critical care medicine · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Narathip Reamaroon
Michael W Sjoding
Kaiwen Lin
Theodore J Iwashyna
Kayvan Najarian

Funding

Data-Driven Identification of the Acute Respiratory Distress SyndromeK01HL136687 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SJODING, MICHAEL WILLIAM · 2017 to 2021
$862k
NHLBI NIH HHS K01 HL136687NHLBI NIH HHS L30 HL138779
6 · The paper itself

Abstract

When training a machine learning algorithm for a supervised-learning task in some clinical applications, uncertainty in the correct labels of some patients may adversely affect the performance of the algorithm. For example, even clinical experts may have less confidence when assigning a medical diagnosis to some patients because of ambiguity in the patient's case or imperfect reliability of the diagnostic criteria. As a result, some cases used in algorithm training may be mislabeled, adversely affecting the algorithm's performance. However, experts may also be able to quantify their diagnostic uncertainty in these cases. We present a robust method implemented with support vector machines (SVM) to account for such clinical diagnostic uncertainty when training an algorithm to detect patients who develop the acute respiratory distress syndrome (ARDS). ARDS is a syndrome of the critically ill that is diagnosed using clinical criteria known to be imperfect. We represent uncertainty in the diagnosis of ARDS as a graded weight of confidence associated with each training label. We also performed a novel time-series sampling method to address the problem of intercorrelation among the longitudinal clinical data from each patient used in model training to limit overfitting. Preliminary results show that we can achieve meaningful improvement in the performance of algorithm to detect patients with ARDS on a hold-out sample, when we compare our method that accounts for the uncertainty of training labels with a conventional SVM algorithm.

Indexed as

Machine LearningSupport Vector MachineDiagnosis, Computer-AssistedHumansRespiratory Distress Syndrome

Identifiers

PMID29994592
PMCPMC6351314

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.