Evidence map›Paper›PMID 29994085›Full record

ArticleIEEE transactions on medical imaging2018

Dictionary-Free MRI PERK: Parameter Estimation via Regression with Kernels.

Gopal Nataraj, Jon-Fredrik Nielsen, Clayton Scott, Jeffrey A Fessler

Abstract read
In one paragraph

Article in IEEE transactions on medical imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Cramér-Rao Bound Optimized Subspace Reconstruction in Quantitative MRI.IEEE transactions on bio-medical engineering · 2025
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  16. Magnetic resonance fingerprinting review part 2: Technique and directions.Journal of magnetic resonance imaging : JMRI · 2020
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gopal Nataraj
Jon-Fredrik Nielsen
Clayton Scott
Jeffrey A Fessler

Funding

Presurgical Planning with Optimized Verbalized Speech Activation Studies inP01CA087634 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MEYER, CHARLES RAYMOND · 2002 to 2013
$14.8M
NCI NIH HHS P01 CA087634
6 · The paper itself

Abstract

This paper introduces a fast, general method for dictionary-free parameter estimation in quantitative magnetic resonance imaging (QMRI) parameter estimation via regression with kernels (PERK). PERK first uses prior distributions and the nonlinear MR signal model to simulate many parameter-measurement pairs. Inspired by machine learning, PERK then takes these parameter-measurement pairs as labeled training points and learns from them a nonlinear regression function using kernel functions and convex optimization. PERK admits a simple implementation as per-voxel nonlinear lifting of MRI measurements followed by linear minimum mean-squared error regression. We demonstrate PERK for $ {\textit {T}_{1}}, {\textit {T}_{2}}$ estimation, a well-studied application where it is simple to compare PERK estimates against dictionary-based grid search estimates and iterative optimization estimates. Numerical simulations as well as single-slice phantom and in vivo experiments demonstrate that PERK and other tested methods produce comparable $ {\textit {T}_{1}}, {\textit {T}_{2}}$ estimates in white and gray matter, but PERK is consistently at least $140\times $ faster. This acceleration factor may increase by several orders of magnitude for full-volume QMRI estimation problems involving more latent parameters per voxel.

Indexed as

AlgorithmsMachine LearningBrainHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingNonlinear Dynamics

Identifiers

PMID29994085
PMCPMC7017957

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.