Evidence map›Paper›PMID 29993603›Full record

ArticleIEEE transactions on visualization and computer graphics2019

Lineage: Visualizing Multivariate Clinical Data in Genealogy Graphs.

Carolina Nobre, Nils Gehlenborg, Hilary Coon, Alexander Lex

Abstract read
In one paragraph

Article in IEEE transactions on visualization and computer graphics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Survey of the intersection of mental maps and visualization.Visual computing for industry, biomedicine, and art · 2026
    Review
  2. ItemComplex: A Python-based visualization framework for ex-post organization and integration of large language-based datasets.European psychiatry : the journal of the Association of European Psychiatrists · 2025
    Article
  3. Aardvark: Composite Visualizations of Trees, Time-Series, and Images.IEEE transactions on visualization and computer graphics · 2025
    Article
  4. KnowNet: Guided Health Information Seeking from LLMs via Knowledge Graph IntegrationIEEE transactions on visualization and computer graphics · 2025
    Article
  5. Juniper: A Tree+ Table Approach to Multivariate Graph Visualization.IEEE transactions on visualization and computer graphics · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Carolina Nobre
Nils Gehlenborg
Hilary Coon
Alexander Lex

Funding

Genetic analysis of high-risk Utah suicide pedigreesR01MH099134 · NIMH · UNIVERSITY OF UTAH · PI COON, HILARY · 2013 to 2017
$3.9M
Visual Analysis of Genomic and Clinical Data from Large Patient CohortsU01CA198935 · NCI · HARVARD MEDICAL SCHOOL · PI PARK, PETER J · 2015 to 2017
$1.5M
Visualization of (Epi)Genomic Data for Discovery of Disease-Associated VariantsR00HG007583 · NHGRI · HARVARD MEDICAL SCHOOL · PI GEHLENBORG, NILS · 2015 to 2017
$727k
NCI NIH HHS U01 CA198935NHGRI NIH HHS R00 HG007583NIMH NIH HHS R01 MH099134
6 · The paper itself

Abstract

The majority of diseases that are a significant challenge for public and individual heath are caused by a combination of hereditary and environmental factors. In this paper we introduce Lineage, a novel visual analysis tool designed to support domain experts who study such multifactorial diseases in the context of genealogies. Incorporating familial relationships between cases with other data can provide insights into shared genomic variants and shared environmental exposures that may be implicated in such diseases. We introduce a data and task abstraction, and argue that the problem of analyzing such diseases based on genealogical, clinical, and genetic data can be mapped to a multivariate graph visualization problem. The main contribution of our design study is a novel visual representation for tree-like, multivariate graphs, which we apply to genealogies and clinical data about the individuals in these families. We introduce data-driven aggregation methods to scale to multiple families. By designing the genealogy graph layout to align with a tabular view, we are able to incorporate extensive, multivariate attributes in the analysis of the genealogy without cluttering the graph. We validate our designs by conducting case studies with our domain collaborators.

Indexed as

Computer GraphicsPedigreeAlgorithmsDatabases, GeneticDiseaseFemaleGenealogy and HeraldryGenomicsHumansMale

Identifiers

PMID29993603
PMCPMC6170727

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.