ArticleIEEE transactions on bio-medical engineering2019
Ultrasonic Microelastography to Assess Biomechanical Properties of the Cornea.
Article in IEEE transactions on bio-medical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Multiscale analysis of equatorial sclera anisotropy: Revealing discrepancies in fiber orientation and mechanical properties.Science advances · 2025Article
- [Anisotropy and viscoelasticity of different corneal regions in rabbit corneal ectasia model].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Article
- In Vivo Evaluation of Corneal Biomechanics Following Cross-Linking Surgeries Using Optical Coherence Elastography in a Rabbit Model of Keratoconus.Translational vision science & technology · 2024Article
- Nonlinear fourth-order elastic characterization of the cornea using torsional wave elastography.Physical and engineering sciences in medicine · 2023Article
- Article
- Simultaneous Assessment of the Whole Eye Biomechanics Using Ultrasonic Elastography.IEEE transactions on bio-medical engineering · 2023Article
- Estimating Thrombus Elasticity by Shear Wave Elastography to Evaluate Ultrasound Thrombolysis for Thrombus With Different Stiffness.IEEE transactions on bio-medical engineering · 2023Article
- In Vivo Evaluation of the Effects of SMILE with Different Amounts of Stromal Ablation on Corneal Biomechanics by Optical Coherence Elastography.Diagnostics (Basel, Switzerland) · 2022Article
- Multiple Optical Elastography Techniques Reveal the Regulation of Corneal Stiffness by Collagen XII.Investigative ophthalmology & visual science · 2022Article
- High-Frequency Ultrasound Elastography to Assess the Nonlinear Elastic Properties of the Cornea and Ciliary Body.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- Torsional wave elastography to assess the mechanical properties of the cornea.Scientific reports · 2022Article
- 2-D Ultrasonic Array-Based Optical Coherence Elastography.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- High resolution optical coherence elastography of retina under prosthetic electrode.Quantitative imaging in medicine and surgery · 2021Article
- Ultrasonic elastography to assess biomechanical properties of the optic nerve head and peripapillary sclera of the eye.Ultrasonics · 2021Article
- Layer-specific ultrasound elastography using a multi-layered shear wave dispersion model for assessing the viscoelastic properties.Physics in medicine and biology · 2021Article
- Current Ultrasound Technologies and Instrumentation in the Assessment and Monitoring of COVID-19 Positive Patients.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2020Review
- Dual-mode ultrasound radiomics and intrinsic imaging phenotypes for diagnosis of lymph node lesions.Annals of translational medicine · 2020Article
- Article
- Ocular Pulse Elastography: Imaging Corneal Biomechanical Responses to Simulated Ocular Pulse Using Ultrasound.Translational vision science & technology · 2020Article
- In vivo evaluation of corneal biomechanical properties by optical coherence elastography at different cross-linking irradiances.Journal of biomedical optics · 2019Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
objectiveTo both qualitatively and quantitatively investigate corneal biomechanical properties through an ultrasonic microelastography imaging system, which is potentially useful in the diagnosis of diseases, such as keratoconus, postrefractive keratectasia, and tracking treatment such as cross-linking surgery.
methodsOur imaging system has a dual-frequency configuration, including a 4.5 MHz ring transducer to push the tissue and a confocally aligned 40 MHz needle transducer to track micron-level displacement. Two-dimensional/three-dimensional acoustic radiation force impulse (ARFI) imaging and Young's modulus in the region of interest were performed on ex vivo porcine corneas that were either cross-linked using formalin solution or preloaded with intraocular pressure (IOPs) from 5 to 30 mmHg.
resultsThe increase of corneal stiffness and the change in cross-linked volume following formalin crosslinking could be precisely observed in the ARFI images and reflected by the reconstructed Young's modulus while the B-mode structural images remained almost unchanged. In addition, the relationship between the stiffness of the cornea and IOPs was investigated among 12 porcine corneas. The corneal stiffness is significantly different at various IOPs and has a tendency to become stiffer with increasing IOP.
conclusionOur results demonstrate the principle of using ultrasonic microelastography techniques to image the biomechanical properties of the cornea. Integrating high-resolution ARFI imaging labeled with reconstructed Young's modulus and structural imaging of the cornea can potentially lead to a routinely performed imaging modality in the field of ophthalmology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.