ArticleIEEE transactions on bio-medical engineering2019
Combined Multiwavelength Photoacoustic and Plane-Wave Ultrasound Imaging for Probing Dynamic Phase-Change Contrast Agents.
Article in IEEE transactions on bio-medical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Synchronization of RF Data in Ultrasound Open Platforms (UOPs) for High-Accuracy and High-Resolution Photoacoustic Tomography Using the "Scissors" Programming Method.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- Article
- Imaging the Activation of Low-Boiling-Point Phase-Change Contrast Agents in the Presence of Tissue Motion Using Ultrafast Inter-frame Activation Ultrasound Imaging.Ultrasound in medicine & biology · 2020Article
- Investigation of light delivery geometries for photoacoustic applications using Monte Carlo simulations with multiple wavelengths, tissue types, and species characteristics.Journal of biomedical optics · 2020Article
- Design and Demonstration of a Configurable Imaging Platform for Combined Laser, Ultrasound, and Elasticity Imaging.IEEE transactions on medical imaging · 2019Article
- Lipid Shell Composition Plays a Critical Role in the Stable Size Reduction of Perfluorocarbon Nanodroplets.Ultrasound in medicine & biology · 2019Article
- Leveraging the Imaging Transmit Pulse to Manipulate Phase-Change Nanodroplets for Contrast-Enhanced Ultrasound.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe purpose of this study was to introduce combined multiwavelength photoacoustic (PA) and plane-wave ultrasound (US) imaging referred to as mwPA/pwUS imaging capable of probing the rapid dynamic behavior of optically activated phase-change contrast agents.
methodsA dedicated mwPA/pwUS imaging sequence was developed based on a programmable US system synchronized with a tunable laser to irradiate tissue with laser pulses at desired optical wavelengths and to acquire post laser pulse PA images followed by ultrafast plane-wave US images. To evaluate the mwPA/pwUS imaging, a capillary filled with optically responsive perfluorohexane nanodroplets (PFHnDs) containing a dye with the peak absorption at 760 nm was imaged with optical wavelengths ranging from 700 to 940 nm. The differences between post-laser ultrafast US images [i.e., differential US (ΔUS)] were taken to visualize the recondensation dynamics of PFHnDs at each wavelength.
resultsThe PA images of PFHnDs showed higher contrast near 760 nm wavelength, corresponding to the peak absorption of the dye encapsulated in the PFHnDs. Moreover, the ΔUS signals immediately after 760-nm pulsed laser irradiation were also high due to the increased US contrast associated with vaporized PFHnDs.
conclusionThe mwPA/pwUS imaging allowed for the US-based optical spectroscopic characterization of PFHnDs and their dynamics. SIGNIFICANCE: The introduced mwPA/pwUS imaging sequence can be used in various clinical applications where both spectroscopic PA imaging of endogenous and/or exogenous chromophores and ultrafast US imaging of phase-change nanodroplets are desired.
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